Browsing Eczacılık Fakültesi by Issue Date
Now showing items 1-20 of 46
-
The production of curcumin-loaded PLGA/PEG nanoparticle for the treatment of Alzheimer’s disease
(Marmara University, 2023)Alzheimer's disease (AD) is the most common type of dementia in the world. This neurodegenerative disease affects 6.5 million people's lives by leading to functional impairments such as memory loss and cognitive regression. ... -
A novel high-efficiency transdermal patches for combinational therapy of Alzheimer's disease: Donepezil/vitamin B12-loaded nanofibers
(Editions de Sante, 2023)Improving clinical practice in disease-modifying therapies is an important strategy in coping with the progressive course of Alzheimer’s Disease (AD). This study aimed to develop DO and VB12-loaded nanofibers (DO/VB12- ... -
The methanolic extracts of Teucrium polium L. and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis improve diabetes in streptozotocin/nicotinamide-induced type 2 diabetic female Sprague Dawley rats
(Elsevier, 2023)Background: Teucrium polium and Micromeria fruticosa subspecies are known to be used in tradi tional medicine for diabetes treatment. Objective: The present study aimed to examine the potential antidiabetic effects and ... -
Sublingual β-Glucan/Vitamin C-loaded nanoparticle-embedded polyethylene oxide nanofibrous mats
(Editions de Sante, 2024)Nutritional supplements available in various forms provide the consumer with essential molecules demanded for well-being retention. Despite the conveniences provided by oral administration, significant disadvantages such ... -
In vitro neuroprotective effect evaluation of donepezil-loaded PLGA nanoparticles-embedded PVA/PEG nanofibers on SH-SY5Y cells and AP-APP plasmid related Alzheimer cell line model
(John Wiley and Sons Inc, 2024)Recently developed nanoparticles and nanofibers present new brain-specific treatment strategies, especially for Alzheimer's disease treatment. In this study, donepezil (DO)-loaded PLGA nanoparticles (DNP) are embedded in ... -
DQAsomes as a coenzyme Q10 delivery vehicle: A step forward therapy in leigh disease
(Springer Nature, 2024)Leigh syndrome (LS), a severe neurometabolic disorder caused by mitochondrial dysfunction, is often linked to coenzyme Q10 (CoQ10) defciency. This study investigated using dequalinium chloride to create CoQ10-loaded ... -
The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus
(Elsevier, 2024)Type 2 Diabetes Mellitus (T2DM) is a growing health concern that leads to increased morbidity and mortality rates worldwide. A protein complex called AMP-activated protein kinase (AMPK) regulates energy balance within ... -
Fabrication of oro-dispersible sodium valproate loaded nanofibrous patches for immediate epileptic innervation
(American Chemical Society, 2024)Epilepsy is one of the oldest neurological disorders discovered by mankind. This condition is firmly coupled with unprovoked seizures stimulated by irrepressible neuroelectrical blasts. Orally taken valproate family has ... -
Development of thermosensitive liposome-containing in-situ gel systems for intranasal administration of thiocolchicoside and in vivo evaluation in a rabbit model
(Taylor and Francis Ltd., 2024)ABSTRACT Aim: Thiocolchicoside (THC) is a drug under the category of BCS III. Due to its high molecular weight, it has poor oral bioavailability and low skin permeability. This study aims to find an alternative delivery ... -
Enhancement of in-vivo cellular uptake of Coenzyme Q10 using saponin derivatives in rTALAP transgenic mice model
(Editions de Sante, 2024)Pancreatic cancer remains a significant contributor to cancer-related mortality, with pancreatic ductal adeno carcinoma (PDAC) being particularly challenging to treat. Coenzyme Q10 (CoQ10), a hydrophobic antioxidant crucial ... -
Anti-Alzheimer's effect of memantine/donepezil/metformin-loaded PVA/PEO composite nanofibers produced by pressurized gyration: Production, characterization, and in vitro evaluation
(Editions de Sante, 2024)In this study, memantine (MM) and donepezil (DO) were combined with metformin (MF) as a new approach to Alzheimer’s disease (AD) treatment sublingually. MM, DO, and MF were loaded in polyvinyl alcohol (PVA)/ polyethylene ... -
Comparison of the effect of UVB application on the antioxidant properties of different mushroom species with vitamins D2 and D3
(Marmara University, 2024)This study aimed to determine the effect of UVB application on different mushrooms and their antioxidant properties and compare their properties with pure vitamins D2 and D3. In the study, as without UVB, with medium UVB ... -
Evaluation of the mesalazine-loaded nanoparticles-embedded BSA hydrogels for the ulcerative colitis treatment
(ACG Publications, 2024)Ulcerative colitis (UC) is a chronic inflammatory bowel disease mainly affecting the colon and remains a challenging disease to manage clinically with its relapsing-remitting course. Traditional treatments for this ... -
Assessing the performance of Coenzyme Q10 loaded DQAsomes to treat Leigh syndrome caused by NDUFS4 knockout
(Editions de Sante, 2024)Homozygous mutations in the NDUFS4 gene result in one of the many autosomal recessive forms of Leigh syndrome (LS), which impairs mitochondrial complex I function. In time, this disorder results in mental and motor ... -
Prolonged release niosomes for ocular delivery of loteprednol: Ocular distribution assessment on dry eye disease induced rabbit model
(Springer, 2024)Loteprednol etabonate (LE) is a topical corticosteroid for the symptomatic management of ocular conditions, encompassing both allergic and infectious etiologies. Owing to the dynamic and static barriers of the eye, LE ... -
Gilaburu (Viburnum opulus L.) fruit extract has potential therapeutic and prophylactic role in a rat model of acetic acid-induced oxidant colonic damage
(Elsevier, 2024)Ethnopharmacological relevance: Ulcerative colitis (UC) which has a global impact on the health care system with its recurrent and incompletely curable characteristics, affects the patients’ quality of life. Gilaburu (GB; ... -
Direct colorimetric detection of triacetone triperoxide explosive by hydroxylamine-mediated Fenton chemistry catalyzed by goethite nanoparticles
(Elsevier, 2024)Due to the absence of nitro groups or aromatic structures in its structure, spectrophotometric methods that can directly determine triacetone triperoxide (TATP) are absent. In the proposed study, a molecular spectroscopic ... -
Donepezil/Curcumin-Loaded Nanoparticles-Embedded Microneedles for the treatment of Alzheimer’s disease: In vitro evaluation
(Avestia Publishing, 2024)Alzheimer’s disease (AD) is an insidious neurodegenerative disease that slowly deteriorates and seriously impairs the activity of daily living (ADL) of those who suffer from. Although the precise pathophysiology of AD ... -
Sublingual administration of Teucrium polium-loaded nanofibers with ultra-fast release in the treatment of diabetes mellitus: In vitro and in vivo evaluation
(Elsevier, 2024)In this study, Teucrium polium (TP) methanolic extract, which has antidiabetic activity and protects the β-cells of the pancreas, was loaded in polyethylene oxide/sodium alginate nanofibers by electrospinning and administered ... -
Diyet türleri
(Ankara Nobel Tıp Kitabevleri, 2024)Sağlıklı bir diyet, aşırı alım olmaksızın enerjik ve fizyolojik ihtiyaçları desteklemek için makro besin öğelerinin uygun oranlarda tüketildiği, aynı zamanda vücudun fizyolojik ihtiyaçlarını karşılamak için yeterli mikro ...
