Güncel Gönderiler: Makale Koleksiyonu
Toplam kayıt 21, listelenen: 1-20
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Preliminary investigations on acyl hydrazones bearing sulfonamides as inhibitors of the human Carbonic Anhydrase isoforms I, II, IX, and XII
(Bentham Science, 2025)Aim: The present study aims to identify the synthesis and structural characterization of acyl hydrazone- sulfonamide-containing compounds that were tested in vitro on human carbonic anhydrase (hCA) isoforms I, II, IX, and ... -
Synthesis of novel thiazole/thiadiazole conjugates of fluoroquinolones as potent antibacterial and antimycobacterial agents
(John Wiley and Sons Inc, 2025)Twenty azole-fluoroquinolone hybrids were designed and synthesized by conjugating thiazole and thiadiazole structures to ciprofloxacin and norfloxacin via a 2-oxoethyl bridge. The structures and purities of the synthesized ... -
Characterization and anti-Alzheimer's effect of donepezil-loaded chitosan/polyethylene glycol nanospheres
(Editions de Sante, 2025)Among numerous dysfunctions associated with Alzheimer’s disease, cholinergic deficiency has been postulated as evidently influential. Despite donepezil’s ability to decelerate disease progression, drug’s pharmacokinetic ... -
The methanolic extracts of Teucrium polium L. and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis improve diabetes in streptozotocin/nicotinamide-induced type 2 diabetic female Sprague Dawley rats
(Elsevier, 2023)Background: Teucrium polium and Micromeria fruticosa subspecies are known to be used in tradi tional medicine for diabetes treatment. Objective: The present study aimed to examine the potential antidiabetic effects and ... -
Vitamin B12-loaded chitosan-based nanoparticle-embedded polymeric nanofibers for sublingual and transdermal applications: Two alternative application routes for vitamin B12
(Elsevier, 2024)Alzheimer’s disease (AD) is a neurodegeneration type that is biologically recognizable via β-amyloid plaques and tau neurofibril tangles. Global estimation for the total count of individuals enduring AD will rise up to ... -
Design and in vitro evaluation of curcumin-loaded PLGA nanoparticle-embedded sodium alginate/gelatin 3D printed scaffolds for Alzheimer’s disease
(Elsevier, 2024)Background: Targeted nanoparticles (NPs) are aimed at improving clinical outcomes by enhancing the diagnostic and therapeutic efficacy of drugs in the treatment of Alzheimer’s disease (AD). Methods: Curcumin (CUR)-loaded ... -
A comparison of electrospinning and pressurized gyration: Production of empagliflozin-loaded polylactic acid/ polycaprolactone fibrous patches
(Royal Soc, 2025)Novel therapeutic strategies are essential for enhancing efficacy and accelerating the treatment of diabetes mellitus. This investigation focused on incorporating empagliflozin into a composite of polylactic acid ... -
Discovery of dual-inhibitor acyl hydrazones for acetylcholinesterase and carbonic anhydrase I/II: A mechanistic insight into Alzheimer's disease
(John Wiley and Sons Inc, 2025)This study presents the synthesis of various non-sulfonamide acyl hydrazone derivatives intended as multi-target ligands for the treatment of Alzheimer's disease. The derivatives were thoroughly characterized using advanced ... -
Antiviral properties of essential oil mixture: Modulation of E7 and E2 protein pathways in human papillomavirus (HPV) infection
(Elsevier, 2024)Ethnopharmacological relevance: Clove is used in Indian and Chinese traditional medicine for viral diseases. Palmarosa essential oils have been traditionally used in India and Southeast Asia since ancient times and ... -
Fabrication of oro-dispersible sodium valproate loaded nanofibrous patches for immediate epileptic innervation
(American Chemical Society, 2024)Epilepsy is one of the oldest neurological disorders discovered by mankind. This condition is firmly coupled with unprovoked seizures stimulated by irrepressible neuroelectrical blasts. Orally taken valproate family has ... -
The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus
(Elsevier, 2024)Type 2 Diabetes Mellitus (T2DM) is a growing health concern that leads to increased morbidity and mortality rates worldwide. A protein complex called AMP-activated protein kinase (AMPK) regulates energy balance within ... -
Sublingual β-Glucan/Vitamin C-loaded nanoparticle-embedded polyethylene oxide nanofibrous mats
(Editions de Sante, 2024)Nutritional supplements available in various forms provide the consumer with essential molecules demanded for well-being retention. Despite the conveniences provided by oral administration, significant disadvantages such ... -
In vitro neuroprotective effect evaluation of donepezil-loaded PLGA nanoparticles-embedded PVA/PEG nanofibers on SH-SY5Y cells and AP-APP plasmid related Alzheimer cell line model
(John Wiley and Sons Inc, 2024)Recently developed nanoparticles and nanofibers present new brain-specific treatment strategies, especially for Alzheimer's disease treatment. In this study, donepezil (DO)-loaded PLGA nanoparticles (DNP) are embedded in ... -
Evaluation of the mesalazine-loaded nanoparticles-embedded BSA hydrogels for the ulcerative colitis treatment
(ACG Publications, 2024)Ulcerative colitis (UC) is a chronic inflammatory bowel disease mainly affecting the colon and remains a challenging disease to manage clinically with its relapsing-remitting course. Traditional treatments for this ... -
Novel hydrazide-hydrazone containing 1,2,4-triazole as potent inhibitors of antiapoptotic protein Bcl-xL: Synthesis, biological evaluation, and docking studies
(John Wiley and Sons Inc, 2024)This study describes the synthesis and characterization of a series of novel hydrazide-hydrazone derivatives containing a 1,2,4-triazole ring. The compounds were characterized using various spectroscopic techniques, such ... -
Comparison of the effect of UVB application on the antioxidant properties of different mushroom species with vitamins D2 and D3
(Marmara University, 2024)This study aimed to determine the effect of UVB application on different mushrooms and their antioxidant properties and compare their properties with pure vitamins D2 and D3. In the study, as without UVB, with medium UVB ... -
Anti-Alzheimer's effect of memantine/donepezil/metformin-loaded PVA/PEO composite nanofibers produced by pressurized gyration: Production, characterization, and in vitro evaluation
(Editions de Sante, 2024)In this study, memantine (MM) and donepezil (DO) were combined with metformin (MF) as a new approach to Alzheimer’s disease (AD) treatment sublingually. MM, DO, and MF were loaded in polyvinyl alcohol (PVA)/ polyethylene ... -
A novel high-efficiency transdermal patches for combinational therapy of Alzheimer's disease: Donepezil/vitamin B12-loaded nanofibers
(Editions de Sante, 2023)Improving clinical practice in disease-modifying therapies is an important strategy in coping with the progressive course of Alzheimer’s Disease (AD). This study aimed to develop DO and VB12-loaded nanofibers (DO/VB12- ... -
Gilaburu (Viburnum opulus L.) fruit extract has potential therapeutic and prophylactic role in a rat model of acetic acid-induced oxidant colonic damage
(Elsevier, 2024)Ethnopharmacological relevance: Ulcerative colitis (UC) which has a global impact on the health care system with its recurrent and incompletely curable characteristics, affects the patients’ quality of life. Gilaburu (GB; ... -
Sublingual administration of Teucrium polium-loaded nanofibers with ultra-fast release in the treatment of diabetes mellitus: In vitro and in vivo evaluation
(Elsevier, 2024)In this study, Teucrium polium (TP) methanolic extract, which has antidiabetic activity and protects the β-cells of the pancreas, was loaded in polyethylene oxide/sodium alginate nanofibers by electrospinning and administered ...
