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Sublingual β-Glucan/Vitamin C-loaded nanoparticle-embedded polyethylene oxide nanofibrous mats
(Editions de Sante, 2024)
Nutritional supplements available in various forms provide the consumer with essential molecules demanded for
well-being retention. Despite the conveniences provided by oral administration, significant disadvantages such ...
In vitro neuroprotective effect evaluation of donepezil-loaded PLGA nanoparticles-embedded PVA/PEG nanofibers on SH-SY5Y cells and AP-APP plasmid related Alzheimer cell line model
(John Wiley and Sons Inc, 2024)
Recently developed nanoparticles and nanofibers present new brain-specific treatment strategies, especially for Alzheimer's disease treatment. In this study, donepezil (DO)-loaded PLGA nanoparticles (DNP) are embedded in ...
The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus
(Elsevier, 2024)
Type 2 Diabetes Mellitus (T2DM) is a growing health concern that leads to increased morbidity
and mortality rates worldwide. A protein complex called AMP-activated protein kinase (AMPK)
regulates energy balance within ...
Fabrication of oro-dispersible sodium valproate loaded nanofibrous patches for immediate epileptic innervation
(American Chemical Society, 2024)
Epilepsy is one of the oldest neurological disorders discovered by mankind. This condition is firmly coupled with unprovoked seizures stimulated by irrepressible neuroelectrical blasts. Orally taken valproate family has ...
The production of curcumin-loaded PLGA/PEG nanoparticle for the treatment of Alzheimer’s disease
(Marmara University, 2023)
Alzheimer's disease (AD) is the most common type of dementia in the world. This neurodegenerative disease affects 6.5 million people's lives by leading to functional impairments such as memory loss and cognitive regression. ...
A novel high-efficiency transdermal patches for combinational therapy of Alzheimer's disease: Donepezil/vitamin B12-loaded nanofibers
(Editions de Sante, 2023)
Improving clinical practice in disease-modifying therapies is an important strategy in coping with the progressive
course of Alzheimer’s Disease (AD). This study aimed to develop DO and VB12-loaded nanofibers (DO/VB12- ...
Anti-Alzheimer's effect of memantine/donepezil/metformin-loaded PVA/PEO composite nanofibers produced by pressurized gyration: Production, characterization, and in vitro evaluation
(Editions de Sante, 2024)
In this study, memantine (MM) and donepezil (DO) were combined with metformin (MF) as a new approach to
Alzheimer’s disease (AD) treatment sublingually. MM, DO, and MF were loaded in polyvinyl alcohol (PVA)/
polyethylene ...
Comparison of the effect of UVB application on the antioxidant properties of different mushroom species with vitamins D2 and D3
(Marmara University, 2024)
This study aimed to determine the effect of UVB application on different mushrooms and their antioxidant
properties and compare their properties with pure vitamins D2 and D3. In the study, as without UVB, with medium UVB ...
Evaluation of the mesalazine-loaded nanoparticles-embedded BSA hydrogels for the ulcerative colitis treatment
(ACG Publications, 2024)
Ulcerative colitis (UC) is a chronic inflammatory bowel disease mainly affecting the colon and remains
a challenging disease to manage clinically with its relapsing-remitting course. Traditional treatments for this ...
Novel hydrazide-hydrazone containing 1,2,4-triazole as potent inhibitors of antiapoptotic protein Bcl-xL: Synthesis, biological evaluation, and docking studies
(John Wiley and Sons Inc, 2024)
This study describes the synthesis and characterization of a series of novel hydrazide-hydrazone derivatives containing a 1,2,4-triazole ring. The compounds were characterized using various spectroscopic techniques, such ...
