İstanbul Kent Üniversitesi Araştırma ve Akademik Performans Sistemi
DSpace@Kent, İstanbul Kent Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
Güncel Gönderiler
Öğe Türü:Öğe, Role of metallic nanoparticles in controlled and targeted drug delivery(CRC Press, 2026) Ergin, Ahmet Doğan; Üner, BurcuThe role of metallic nanoparticles in controlled and targeted drug delivery is a rapidly evolving field, promising to revolutionize modern medicine. This chapter explores the unique properties of mostly used metallic nanoparticles, including gold, silver, iron, zinc oxide, cerium oxide, and titanium dioxide, and their applications in enhancing drug delivery systems. By leveraging surface functionalization and targeting capabilities, these nanoparticles can improve the efficacy and precision of therapeutic interventions. Gold and iron nanoparticles are highlighted for their superior performance in targeted drug delivery, while zinc oxide and titanium dioxide offer cost-effective and biocompatible alternatives. However, challenges such as varying biocompatibility, potential toxicity, scalability, and regulatory hurdles must be addressed. This chapter highlights the importance of ongoing research and optimization in nanoparticle design to address these challenges. By advancing the application of metallic nanoparticles, we can achieve more effective, personalized, and safer drug delivery systems, significantly improving patient outcomes and healthcare quality.Öğe Türü:Öğe, Nanoparticle strategies for enhanced protein and peptide drug delivery(CRC Press, 2026) Üner, Burcu; Ergin, Ahmet Doğan; Dwivedi, PankajThe delivery of protein and peptide therapeutics presents substantial challenges due to their inherent instability, vulnerability to enzymatic degradation, and low bioavailability. Nanoparticle-based delivery systems offer promising solutions, providing protection, controlled release, and targeted delivery for these therapeutic agents. This chapter provides a detailed overview of the various nanoparticle types used in protein and peptide drug delivery, including polymeric, lipid-based, inorganic, and hybrid nanoparticles. We delve into the methods of encapsulation and release, along with strategies to enhance the stability and bioavailability of these bioactive compounds. We examine various administration routes and targeting strategies that leverage nanoparticles’ unique properties to enhance therapeutic effectiveness. This chapter also covers the in vitro and in vivo evaluation of nanoparticle systems, detailing key techniques and models used to assess their efficacy and safety. Clinical applications across diverse therapeutic fields are highlighted, illustrating the potential of nanoparticle-based delivery systems to transform treatments for diseases like cancer, diabetes, and infections. Regulatory and manufacturing aspects are discussed, providing insights into the challenges and requirements for commercializing nanoparticle-based protein and peptide drug delivery systems. Lastly, we explore future perspectives and challenges, emphasizing emerging trends and potential research directions that could further advance this field. This chapter aims to be a valuable resource for researchers, clinicians, and industry professionals involved in the development and application of nanoparticle-based delivery systems for protein and peptide therapies.Öğe Türü:Öğe, The future of “ecocide” as the fifth crime in international law in the context of environmental security(Burdur Mehmet Akif Ersoy University, 2026) Taşlıcalı Koç, Tuba; Çomak, HasretAfter the Cold War, the approach to international security in IR shifted, highlighting that harmony in the global system relies on various actors and conditions. In this context, new security perception approaches have emerged and are now analyzed through five sectors instead of a realistic perspective. According to the five-sector analysis approach introduced by the Copenhagen School, security studies now include not only military but also political, economic, environmental, and social elements. While significant strides have been made in enhancing environmental security ongoing environmental challenges and their associated impacts suggest that these initiatives cannot find enough support in the international juridical system. For this reason, the concept of “ecocide” was developed by international actors, which many countries included in their legal systems with a further aim of preventing crimes against the environment by taking its place in international law with the scope of enhancing international security. This study aims to explore the implications of the concept of "ecocide" within the international legal system, particularly in relation to environmental security and emerging security frameworks and its impact on international security. The research utilizes a document analysis method to achieve this goal. Given the importance of the subject matter, this study is poised to make a meaningful contribution to humanity by offering insights into the preventability of environmental pollution, a pressing threat to the environment, and therefore to international security.Öğe Türü:Öğe, Comparison of the intaglio surface accuracy of occlusal veneers fabricated using two different techniques to restore severe occlusal tooth wear: An in vitro study(Elsevier, 2026) Kaffaf, Mehmet Berk; Şeşen, Pınar; Ok Tokaç, SinemStatement of problem: Intaglio surface accuracy is essential for the proper fit and clinical performance of occlusal veneers. Comparative data on subtractive and additive methods for occlusal veneers fabricated from patient-derived casts with severe tooth wear are limited. Purpose: The purpose of this in vitro study was to evaluate the trueness and precision of occlusal veneers fabricated by subtractive milling (Tetric CAD; Ivoclar AG) and additive manufacturing (Saremco print CROWNTEC; Saremco Dental AG) in a severely worn molar using a patient-derived cast under laboratory conditions. Material and methods: A digital scan of the mandibular first molar tooth of a patient with severe occlusal wear was obtained using an intraoral scanner. Occlusal veneers were digitally designed and fabricated by milling (n=20) or 3-dimensional printing (n=20). Intaglio surface scans were compared with the reference design in the Geomagic Control X software program to assess trueness; precision was determined by pairwise alignment within groups. Data normality was assessed with Kolmogorov-Smirnov and Shapiro-Wilk tests, and groups were compared with the Mann-Whitney U test (α=.05). Results: Trueness was significantly higher in the milling group (P<.05), while no significant difference in precision was observed (P>.05). Both materials showed trueness values within clinically acceptable limits (≤200 µm). Conclusions: Subtractive milling produced more accurate intaglio surfaces than additive manufacturing, though both methods demonstrated acceptable adaptation and similar reproducibility. Although both methods appear to be clinically applicable, subtractive manufacturing offers higher trueness, whereas additive manufacturing provides advantages in material and cost efficiency.Öğe Türü:Öğe, Impact of operating room personnel density on aerobiome-related infection risk in penile implant surgery(Oxford University Press, 2026) Albayrak, Ahmet Tevfik; Başağa, Yaşar; Sökmen, Doğukan; Uçak, Şafak Ceren; Aktaş, Ahmet; Sertkaya, Zülfü; Şerefoğlu, Ege CanBackground Erectile dysfunction refractory to medical therapy is most effectively treated with inflatable penile prosthesis (IPP) implantation, yet infection remains the principal complication. Operating room traffic and airborne exposure have long been suspected contributors, though their impact on prosthetic urology remains unexamined. Aim To evaluate whether operating room personnel density, as a surrogate for aerobiome burden, contributes to microbial colonization of IPPs under sterile surgical conditions. Methods An ex vivo experimental study was conducted using Rigicon® Infla10X IPP without antibiotic coating. The device was exposed for 45 min to 4 real-world operating room scenarios with varying personnel densities: 4 (standard surgery), 8 (dual-surgeon team), 16 (educational surgery), and 32 (masterclass). The IPP was swabbed at reservoir, pump, and cylinders. Samples underwent DNA extraction, full-length 16S rRNA sequencing (Oxford Nanopore Technologies, Oxford, UK), and quantitative polymerase chain reaction (qPCR). Positive controls (Escherichia coli ATCC 25992) were included. Outcomes The primary outcome was microbial colonization of IPPs, defined as detectable microbial DNA by sequencing or qPCR across personnel-density groups. Results No microbial DNA was detected in any of the 12 swabbed IPP samples across all groups, whereas the positive controls amplified successfully, confirming methodological validity. Personnel density did not influence microbial colonization, with uniformly negative results in 4-, 8-, 16-, and 32-staff conditions. Clinical Implications This study demonstrated that operating room personnel density was not associated with increased microbial colonization of IPP via airborne exposure. The results support the safety of educational and live-surgery settings with larger teams when strict sterility protocols are followed. Strengths and Limitations Strengths include a controlled ex vivo design, simulation of real-world surgical conditions, and comprehensive microbial assessment using next-generation sequencing with qPCR. Limitations include the ex vivo nature of the study, evaluation of a single IPP model without antibiotic coating, and limited exposure duration of 3 hours. Conclusion Operating room personnel density did not influence microbial colonization of IPPs under sterile conditions. Airborne exposure may not be a primary factor in the pathogenesis of IPP infection, underscoring the importance of alternative contributors, such as skin-to-implant contact. Further ex vivo and in vivo studies are warranted to clarify infection mechanisms.
