Yazar "Çelik, Aybüke" için listeleme
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Assessing the performance of Coenzyme Q10 loaded DQAsomes to treat Leigh syndrome caused by NDUFS4 knockout
Üner, Burcu; Ergin, Ahmet Doğan; Çelik, Aybüke; Khatik, Renuka; Dwivedi, Pankaj (Editions de Sante, 2024)Homozygous mutations in the NDUFS4 gene result in one of the many autosomal recessive forms of Leigh syndrome (LS), which impairs mitochondrial complex I function. In time, this disorder results in mental and motor ... -
DQAsomes as a coenzyme Q10 delivery vehicle: A step forward therapy in leigh disease
Ergin, Ahmet Doğan; Seçen, Erhan; Çelik, Aybüke; Üner, Burcu (Springer Nature, 2024)Leigh syndrome (LS), a severe neurometabolic disorder caused by mitochondrial dysfunction, is often linked to coenzyme Q10 (CoQ10) defciency. This study investigated using dequalinium chloride to create CoQ10-loaded ... -
Enhancement of in-vivo cellular uptake of Coenzyme Q10 using saponin derivatives in rTALAP transgenic mice model
Üner, Burcu; Çelik, Aybüke; Ergin, Ahmet Doğan; Altay Benetti, Ayça; Benetti, Camillo (Editions de Sante, 2024)Pancreatic cancer remains a significant contributor to cancer-related mortality, with pancreatic ductal adeno carcinoma (PDAC) being particularly challenging to treat. Coenzyme Q10 (CoQ10), a hydrophobic antioxidant crucial ...
