Yazar "Üner, Burcu" için listeleme
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Antiviral properties of essential oil mixture: Modulation of E7 and E2 protein pathways in human papillomavirus (HPV) infection
Üner, Burcu; Güler, Ece; Vicir, Mustafa Emrah; Kayhan, Hülya; Atsü, Necmettin; Kalaskar, Deepak; Çam, Muhammet Emin (Elsevier, 2024)Ethnopharmacological relevance: Clove is used in Indian and Chinese traditional medicine for viral diseases. Palmarosa essential oils have been traditionally used in India and Southeast Asia since ancient times and ... -
Assessing the performance of Coenzyme Q10 loaded DQAsomes to treat Leigh syndrome caused by NDUFS4 knockout
Üner, Burcu; Ergin, Ahmet Doğan; Çelik, Aybüke; Khatik, Renuka; Dwivedi, Pankaj (Editions de Sante, 2024)Homozygous mutations in the NDUFS4 gene result in one of the many autosomal recessive forms of Leigh syndrome (LS), which impairs mitochondrial complex I function. In time, this disorder results in mental and motor ... -
Design and in vitro evaluation of curcumin-loaded PLGA nanoparticle-embedded sodium alginate/gelatin 3D printed scaffolds for Alzheimer’s disease
Yekeler, Hümeyra Betül; Güler, Ece; Beato, Patricia Santos; Priya, Sushma; Abobakr, Fatima Khaled Mohammed; Doğan, Murat; Üner, Burcu; Kalaskar, Deepak M.; Çam, Muhammet Emin (Elsevier, 2024)Background: Targeted nanoparticles (NPs) are aimed at improving clinical outcomes by enhancing the diagnostic and therapeutic efficacy of drugs in the treatment of Alzheimer’s disease (AD). Methods: Curcumin (CUR)-loaded ... -
Development of thermosensitive liposome-containing in-situ gel systems for intranasal administration of thiocolchicoside and in vivo evaluation in a rabbit model
Üner, Burcu; Baranauskaite Ortasöz, Juste; Taş, Çetin (Taylor and Francis Ltd., 2024)ABSTRACT Aim: Thiocolchicoside (THC) is a drug under the category of BCS III. Due to its high molecular weight, it has poor oral bioavailability and low skin permeability. This study aims to find an alternative delivery ... -
DQAsomes as a coenzyme Q10 delivery vehicle: A step forward therapy in leigh disease
Ergin, Ahmet Doğan; Seçen, Erhan; Çelik, Aybüke; Üner, Burcu (Springer Nature, 2024)Leigh syndrome (LS), a severe neurometabolic disorder caused by mitochondrial dysfunction, is often linked to coenzyme Q10 (CoQ10) defciency. This study investigated using dequalinium chloride to create CoQ10-loaded ... -
Enhancement of in-vivo cellular uptake of Coenzyme Q10 using saponin derivatives in rTALAP transgenic mice model
Üner, Burcu; Çelik, Aybüke; Ergin, Ahmet Doğan; Altay Benetti, Ayça; Benetti, Camillo (Editions de Sante, 2024)Pancreatic cancer remains a significant contributor to cancer-related mortality, with pancreatic ductal adeno carcinoma (PDAC) being particularly challenging to treat. Coenzyme Q10 (CoQ10), a hydrophobic antioxidant crucial ... -
Fabrication of oro-dispersible sodium valproate loaded nanofibrous patches for immediate epileptic innervation
Güler, Ece; Yekeler, Hümeyra Betül; Özdemir Kumral, Zarife N.; Parviz, Gita; Özcan, Gül S.; Üner, Burcu; Demirbaş, Sinem G.; Ayyıldız, Simge; Yazır, Yusufhan; Kalaskar, Deepak; Çam, Muhammet Emin (American Chemical Society, 2024)Epilepsy is one of the oldest neurological disorders discovered by mankind. This condition is firmly coupled with unprovoked seizures stimulated by irrepressible neuroelectrical blasts. Orally taken valproate family has ... -
In vitro neuroprotective effect evaluation of donepezil-loaded PLGA nanoparticles-embedded PVA/PEG nanofibers on SH-SY5Y cells and AP-APP plasmid related Alzheimer cell line model
Güler, Ece; Yekeler, Hümeyra Betül; Üner, Burcu; Doğan, Murat; Asghar, Asima; Ikram, Fakhera; Yazır, Yusufhan; Gündüz, Oğuzhan; Kalaskar, Deepak M.; Çam, Muhammet Emin (John Wiley and Sons Inc, 2024)Recently developed nanoparticles and nanofibers present new brain-specific treatment strategies, especially for Alzheimer's disease treatment. In this study, donepezil (DO)-loaded PLGA nanoparticles (DNP) are embedded in ... -
Mitochondria-targeted spathulenol-loaded retinosomes for age-related macular degeneration
Üner, Burcu; Kirichok, Yuriy; Güler, Elif (Kızılay Culture and Art, 2025)Age-related macular degeneration (AMD) is a leading cause of vision loss, with mitochondrial dysfunction playing a key role in its progression. This study explores the use of spathulenol, a natural sesquiterpene with ... -
Multikinase inhibition-mediated proliferative vitreoretinopathy therapy by nanoparticles in rabbits
Arslan, Elif; Öztürk, Faruk; Üner, Burcu; Türeli, Serkan; Müftüoğlu, Sevda Fatma; Taş, Çetin (Molecular Vision, 2025)Purpose: To investigate the efficacy of nanoparticles in treating proliferative vitreoretinopathy (PVR) through clinical observation, histology, and immunohistochemistry, despite unsatisfactory surgical outcomes and failed ... -
Novel hydrazide-hydrazone containing 1,2,4-triazole as potent inhibitors of antiapoptotic protein Bcl-xL: Synthesis, biological evaluation, and docking studies
Kuran, Ebru Didem; Üner, Burcu; Çam, Muhammet Emin; Ulusoy Güzeldemirci, Nuray (John Wiley and Sons Inc, 2024)This study describes the synthesis and characterization of a series of novel hydrazide-hydrazone derivatives containing a 1,2,4-triazole ring. The compounds were characterized using various spectroscopic techniques, such ... -
Prolonged release niosomes for ocular delivery of loteprednol: Ocular distribution assessment on dry eye disease induced rabbit model
Özdemir, Samet; Üner, Burcu (Springer, 2024)Loteprednol etabonate (LE) is a topical corticosteroid for the symptomatic management of ocular conditions, encompassing both allergic and infectious etiologies. Owing to the dynamic and static barriers of the eye, LE ... -
Targeted ‘Tfam’ activation and ‘Mitoq’ therapy for pearson syndrome
Tuzcu, Bilge; Üner, Burcu (Kızılay Culture and Art, 2025)This study investigates a novel therapeutic strategy for Pearson syndrome by combining Mitochondrial Transcription Factor A (TFAM) activation with the antioxidant MitoQ in a dual-loaded nanoparticle system. Pearson syndrome, ...
