Yazar "Kalaskar, Deepak M." için listeleme
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Anti-Alzheimer's effect of memantine/donepezil/metformin-loaded PVA/PEO composite nanofibers produced by pressurized gyration: Production, characterization, and in vitro evaluation
Güler, Ece; Kopuz, Ayşen; Ertaş, Büşra; Yılmaz Göler, Ayşe Mine; Yazır, Yusufhan; Kalaskar, Deepak M.; Çam, Muhammet Emin (Editions de Sante, 2024)In this study, memantine (MM) and donepezil (DO) were combined with metformin (MF) as a new approach to Alzheimer’s disease (AD) treatment sublingually. MM, DO, and MF were loaded in polyvinyl alcohol (PVA)/ polyethylene ... -
Characterization and anti-Alzheimer's effect of donepezil-loaded chitosan/polyethylene glycol nanospheres
Parviz, Gita; Güler, Ece; Hazar Yavuz, Ayşe Nur; Yekeler, Hümeyra Betül; Tatar, Esra; Koçar, Feyza; Sermet, Sinan; Asghar, Asima; Wang, Xiaofeng; Ikram, Fakhera; Kalaskar, Deepak M.; Çam, Muhammet Emin (Editions de Sante, 2025)Among numerous dysfunctions associated with Alzheimer’s disease, cholinergic deficiency has been postulated as evidently influential. Despite donepezil’s ability to decelerate disease progression, drug’s pharmacokinetic ... -
A comparison of electrospinning and pressurized gyration: Production of empagliflozin-loaded polylactic acid/ polycaprolactone fibrous patches
Yekeler, Hümeyra Betül; Kabaoğlu, İlke; Güler, Ece; Graça, Manuel Pedro F.; Gündüz, Oğuzhan; Kalaskar, Deepak M.; Çam, Muhammet Emin (Royal Soc, 2025)Novel therapeutic strategies are essential for enhancing efficacy and accelerating the treatment of diabetes mellitus. This investigation focused on incorporating empagliflozin into a composite of polylactic acid ... -
Design and in vitro evaluation of curcumin-loaded PLGA nanoparticle-embedded sodium alginate/gelatin 3D printed scaffolds for Alzheimer’s disease
Yekeler, Hümeyra Betül; Güler, Ece; Beato, Patricia Santos; Priya, Sushma; Abobakr, Fatima Khaled Mohammed; Doğan, Murat; Üner, Burcu; Kalaskar, Deepak M.; Çam, Muhammet Emin (Elsevier, 2024)Background: Targeted nanoparticles (NPs) are aimed at improving clinical outcomes by enhancing the diagnostic and therapeutic efficacy of drugs in the treatment of Alzheimer’s disease (AD). Methods: Curcumin (CUR)-loaded ... -
In vitro neuroprotective effect evaluation of donepezil-loaded PLGA nanoparticles-embedded PVA/PEG nanofibers on SH-SY5Y cells and AP-APP plasmid related Alzheimer cell line model
Güler, Ece; Yekeler, Hümeyra Betül; Üner, Burcu; Doğan, Murat; Asghar, Asima; Ikram, Fakhera; Yazır, Yusufhan; Gündüz, Oğuzhan; Kalaskar, Deepak M.; Çam, Muhammet Emin (John Wiley and Sons Inc, 2024)Recently developed nanoparticles and nanofibers present new brain-specific treatment strategies, especially for Alzheimer's disease treatment. In this study, donepezil (DO)-loaded PLGA nanoparticles (DNP) are embedded in ... -
Vitamin B12-loaded chitosan-based nanoparticle-embedded polymeric nanofibers for sublingual and transdermal applications: Two alternative application routes for vitamin B12
Güler, Ece; Yekeler, Hümeyra Betül; Parviz, Gita; Aydın, Saliha; Asghar, Asima; Doğan, Murat; Ikram, Fakhera; Kalaskar, Deepak M.; Çam, Muhammet Emin (Elsevier, 2024)Alzheimer’s disease (AD) is a neurodegeneration type that is biologically recognizable via β-amyloid plaques and tau neurofibril tangles. Global estimation for the total count of individuals enduring AD will rise up to ...
