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Characterization and anti-Alzheimer's effect of donepezil-loaded chitosan/polyethylene glycol nanospheres
Parviz, Gita; Güler, Ece; Hazar Yavuz, Ayşe Nur; Yekeler, Hümeyra Betül; Tatar, Esra; Koçar, Feyza; Sermet, Sinan; Asghar, Asima; Wang, Xiaofeng; Ikram, Fakhera; Kalaskar, Deepak M.; Çam, Muhammet Emin (Editions de Sante, 2025)Among numerous dysfunctions associated with Alzheimer’s disease, cholinergic deficiency has been postulated as evidently influential. Despite donepezil’s ability to decelerate disease progression, drug’s pharmacokinetic ... -
The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus
Aydın, Saliha; Tekinalp, Şevval Gülşah; Tuzcu, Bilge; Furkan, Çam; Sevik, Mehmet Orkun; Tatar, Esra; Kalaskar, Deepak; Çam, Muhammet Emin (Elsevier, 2024)Type 2 Diabetes Mellitus (T2DM) is a growing health concern that leads to increased morbidity and mortality rates worldwide. A protein complex called AMP-activated protein kinase (AMPK) regulates energy balance within ... -
Synthesis of novel thiazole/thiadiazole conjugates of fluoroquinolones as potent antibacterial and antimycobacterial agents
Poyraz Yılmaz, Pınar; Kulabaş, Necla; Bozdeveci, Arif; Vagolu, Siva Krishna; Imran, Mohd; Tatar, Esra; Alpay Karaoğlu, Şengül; Sriram, Dharmarajan; Mahmood, Ammar A. Razzak; Küçükgüzel, İlkay (John Wiley and Sons Inc, 2025)Twenty azole-fluoroquinolone hybrids were designed and synthesized by conjugating thiazole and thiadiazole structures to ciprofloxacin and norfloxacin via a 2-oxoethyl bridge. The structures and purities of the synthesized ...
