Yazar "Yekeler, Hümeyra Betül" için listeleme
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Characterization and anti-Alzheimer's effect of donepezil-loaded chitosan/polyethylene glycol nanospheres
Parviz, Gita; Güler, Ece; Hazar Yavuz, Ayşe Nur; Yekeler, Hümeyra Betül; Tatar, Esra; Koçar, Feyza; Sermet, Sinan; Asghar, Asima; Wang, Xiaofeng; Ikram, Fakhera; Kalaskar, Deepak M.; Çam, Muhammet Emin (Editions de Sante, 2025)Among numerous dysfunctions associated with Alzheimer’s disease, cholinergic deficiency has been postulated as evidently influential. Despite donepezil’s ability to decelerate disease progression, drug’s pharmacokinetic ... -
A comparison of electrospinning and pressurized gyration: Production of empagliflozin-loaded polylactic acid/ polycaprolactone fibrous patches
Yekeler, Hümeyra Betül; Kabaoğlu, İlke; Güler, Ece; Graça, Manuel Pedro F.; Gündüz, Oğuzhan; Kalaskar, Deepak M.; Çam, Muhammet Emin (Royal Soc, 2025)Novel therapeutic strategies are essential for enhancing efficacy and accelerating the treatment of diabetes mellitus. This investigation focused on incorporating empagliflozin into a composite of polylactic acid ... -
Design and in vitro evaluation of curcumin-loaded PLGA nanoparticle-embedded sodium alginate/gelatin 3D printed scaffolds for Alzheimer’s disease
Yekeler, Hümeyra Betül; Güler, Ece; Beato, Patricia Santos; Priya, Sushma; Abobakr, Fatima Khaled Mohammed; Doğan, Murat; Üner, Burcu; Kalaskar, Deepak M.; Çam, Muhammet Emin (Elsevier, 2024)Background: Targeted nanoparticles (NPs) are aimed at improving clinical outcomes by enhancing the diagnostic and therapeutic efficacy of drugs in the treatment of Alzheimer’s disease (AD). Methods: Curcumin (CUR)-loaded ... -
Development of sublingual nanofibrous mats for enhanced nutrient delivery: A novel approach using chitosan-based nanoparticles
Güler, Ece; Yekeler, Hümeyra Betül; Tekinalp, Şevval Gülşah; Parviz, Gita; Doğan, Murat; Ekentok, Ceyda; Çam, Muhammet Emin (ICEMES, 2025)There are many different types of dietary supplements that provide vital chemicals to the people they need to stay healthy. Oral administration offers convenience, yet it also presents notable drawbacks, including the ... -
Fabrication of oro-dispersible sodium valproate loaded nanofibrous patches for immediate epileptic innervation
Güler, Ece; Yekeler, Hümeyra Betül; Özdemir Kumral, Zarife N.; Parviz, Gita; Özcan, Gül S.; Üner, Burcu; Demirbaş, Sinem G.; Ayyıldız, Simge; Yazır, Yusufhan; Kalaskar, Deepak; Çam, Muhammet Emin (American Chemical Society, 2024)Epilepsy is one of the oldest neurological disorders discovered by mankind. This condition is firmly coupled with unprovoked seizures stimulated by irrepressible neuroelectrical blasts. Orally taken valproate family has ... -
In vitro neuroprotective effect evaluation of donepezil-loaded PLGA nanoparticles-embedded PVA/PEG nanofibers on SH-SY5Y cells and AP-APP plasmid related Alzheimer cell line model
Güler, Ece; Yekeler, Hümeyra Betül; Üner, Burcu; Doğan, Murat; Asghar, Asima; Ikram, Fakhera; Yazır, Yusufhan; Gündüz, Oğuzhan; Kalaskar, Deepak M.; Çam, Muhammet Emin (John Wiley and Sons Inc, 2024)Recently developed nanoparticles and nanofibers present new brain-specific treatment strategies, especially for Alzheimer's disease treatment. In this study, donepezil (DO)-loaded PLGA nanoparticles (DNP) are embedded in ... -
Investigation of the antimicrobial activity of some plant extracts
Yekeler, Hümeyra Betül; Rayaman, Erkan; Çam, Muhammet Emin (Kızılay Culture and Art, 2025)The use of antimicrobial plants in mineral water prevents the growth of pathogenic microorganisms, extends the shelf life of the product, and pro vides a natural alternative to chemical preservatives (1). Furthermore, ... -
Sublingual β-Glucan/Vitamin C-loaded nanoparticle-embedded polyethylene oxide nanofibrous mats
Güler, Ece; Yekeler, Hümeyra Betül; Tekinalp, Şevval Gülşah; Parviz, Gita; Doğan, Murat; Ekentok, Ceyda; Çam, Muhammet Emin (Editions de Sante, 2024)Nutritional supplements available in various forms provide the consumer with essential molecules demanded for well-being retention. Despite the conveniences provided by oral administration, significant disadvantages such ... -
Vitamin B12-loaded chitosan-based nanoparticle-embedded polymeric nanofibers for sublingual and transdermal applications: Two alternative application routes for vitamin B12
Güler, Ece; Yekeler, Hümeyra Betül; Parviz, Gita; Aydın, Saliha; Asghar, Asima; Doğan, Murat; Ikram, Fakhera; Kalaskar, Deepak M.; Çam, Muhammet Emin (Elsevier, 2024)Alzheimer’s disease (AD) is a neurodegeneration type that is biologically recognizable via β-amyloid plaques and tau neurofibril tangles. Global estimation for the total count of individuals enduring AD will rise up to ...
