Browsing Makale Koleksiyonu by Issue Date
Now showing items 1-10 of 10
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In vitro neuroprotective effect evaluation of donepezil-loaded PLGA nanoparticles-embedded PVA/PEG nanofibers on SH-SY5Y cells and AP-APP plasmid related Alzheimer cell line model
(John Wiley and Sons Inc, 2024)Recently developed nanoparticles and nanofibers present new brain-specific treatment strategies, especially for Alzheimer's disease treatment. In this study, donepezil (DO)-loaded PLGA nanoparticles (DNP) are embedded in ... -
DQAsomes as a coenzyme Q10 delivery vehicle: A step forward therapy in leigh disease
(Springer Nature, 2024)Leigh syndrome (LS), a severe neurometabolic disorder caused by mitochondrial dysfunction, is often linked to coenzyme Q10 (CoQ10) defciency. This study investigated using dequalinium chloride to create CoQ10-loaded ... -
Fabrication of oro-dispersible sodium valproate loaded nanofibrous patches for immediate epileptic innervation
(American Chemical Society, 2024)Epilepsy is one of the oldest neurological disorders discovered by mankind. This condition is firmly coupled with unprovoked seizures stimulated by irrepressible neuroelectrical blasts. Orally taken valproate family has ... -
Development of thermosensitive liposome-containing in-situ gel systems for intranasal administration of thiocolchicoside and in vivo evaluation in a rabbit model
(Taylor and Francis Ltd., 2024)ABSTRACT Aim: Thiocolchicoside (THC) is a drug under the category of BCS III. Due to its high molecular weight, it has poor oral bioavailability and low skin permeability. This study aims to find an alternative delivery ... -
Enhancement of in-vivo cellular uptake of Coenzyme Q10 using saponin derivatives in rTALAP transgenic mice model
(Editions de Sante, 2024)Pancreatic cancer remains a significant contributor to cancer-related mortality, with pancreatic ductal adeno carcinoma (PDAC) being particularly challenging to treat. Coenzyme Q10 (CoQ10), a hydrophobic antioxidant crucial ... -
Novel hydrazide-hydrazone containing 1,2,4-triazole as potent inhibitors of antiapoptotic protein Bcl-xL: Synthesis, biological evaluation, and docking studies
(John Wiley and Sons Inc, 2024)This study describes the synthesis and characterization of a series of novel hydrazide-hydrazone derivatives containing a 1,2,4-triazole ring. The compounds were characterized using various spectroscopic techniques, such ... -
Assessing the performance of Coenzyme Q10 loaded DQAsomes to treat Leigh syndrome caused by NDUFS4 knockout
(Editions de Sante, 2024)Homozygous mutations in the NDUFS4 gene result in one of the many autosomal recessive forms of Leigh syndrome (LS), which impairs mitochondrial complex I function. In time, this disorder results in mental and motor ... -
Prolonged release niosomes for ocular delivery of loteprednol: Ocular distribution assessment on dry eye disease induced rabbit model
(Springer, 2024)Loteprednol etabonate (LE) is a topical corticosteroid for the symptomatic management of ocular conditions, encompassing both allergic and infectious etiologies. Owing to the dynamic and static barriers of the eye, LE ... -
Design and in vitro evaluation of curcumin-loaded PLGA nanoparticle-embedded sodium alginate/gelatin 3D printed scaffolds for Alzheimer’s disease
(Elsevier, 2024)Background: Targeted nanoparticles (NPs) are aimed at improving clinical outcomes by enhancing the diagnostic and therapeutic efficacy of drugs in the treatment of Alzheimer’s disease (AD). Methods: Curcumin (CUR)-loaded ... -
A novel liposomal in-situ hydrogel formulation of hypericum perforatum L.: In vitro characterization and in vivo wound healing studies
(MDPI, 2025)Hypericum perforatum L. (H.P.) is a species with a well-documented history of use in wound healing practices across the globe. The objective of this study was twofold: firstly, to evaluate the in vivo efficacy of liposomal ...
