İstanbul Kent Üniversitesi Araştırma ve Akademik Performans Sistemi
DSpace@Kent, İstanbul Kent Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
Güncel Gönderiler
Öğe Türü:Öğe, Comprehensive phytochemical profiling and bioactivity assessment of the endemic Hypericum heterophyllum: Chemotypic variation revealed through validated LC–MS/MS analysis(Elsevier, 2026) İnan, Gözde Gülin; Doğanay, Derya; İnan, Yiğit; Akyüz Çetin, Selin; Neşetoğlu, Neşet; Danış, İbrahim; Özkanca, Cemre; Ünal, Durişehvar Özer; Zengin, GökhanHypericum heterophyllum Vent., an endemic species of Türkiye, was investigated for its phytochemical compo sition and biological activities using two populations (HHA: Ankara population and HHB: Afyonkarahisar pop ulation) collected from distinct geographical regions. The 80% ethanolic extracts were evaluated for total phenolic and flavonoid content, antioxidant capacity, antimicrobial activity, enzyme inhibitory effects, and detailed metabolite profiling through a fully validated liquid chromatography–tandem mass spectrometry (LC–MS/MS) method. Among the two populations, HHA exhibited higher total phenolic and flavonoid contents, which were associated with significantly stronger antioxidant activities across multiple assays. Furthermore, HHA showed more pronounced α-glucosidase inhibitory activity compared to HHB, whereas α-amylase and cholinesterase inhibition remained weak to moderate and population-dependent. LC–MS/MS analysis identified neochlorogenic acid, hyperoside, quercitrin, catechin, and procyanidin B2 as the principal metabolites driving these activities. Both extracts exhibited complex and phenolic-rich chemical profiles; however, HHA consistently contained higher levels of major caffeoylquinic acids, flavonoids, and flavan-3-ols, which was reflected in su perior antioxidant performance (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6- sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), and cupric reducing antioxidant capacity (CUPRAC)), stronger tyrosinase and α-glucosidase inhibition, and enhanced antimicrobial activity—particularly against Gram-positive bacteria—compared to HHB. Overall, H. heterophyllum, especially the HHA chemotype, emerges as a promising natural source of bioactive compounds with potential applications in nutraceutical and pharmaceutical fields.Öğe Türü:Öğe, Is it possible to find meaning in life after adverse childhood experiences? Hope and loneliness as serial mediators(Elsevier, 2026) Çelik Örnek, Dilaram BillurBackground: Adverse childhood experiences, such as neglect and abuse in childhood, can significantly harm the mental and physical health of individuals and form the basis for the belief that the world is an unreliable, meaningless, and unjust place. Objective: This study investigates the mediating role of hope and loneliness in individuals who had experienced adverse childhood experiences in pursuing a meaningful life. Methods: The study cohort consisted of 419 adults who participated voluntarily. The Socio-demographic Infor mation Form, Adverse Childhood Experiences Scale, Dispositional Hope Scale, Revised UCLA Loneliness Scale, and Meaning in Life Scale were used for data collection. Results: Adverse childhood experiences were negatively associated with hope (r = − 0.157, p < 0.001) and meaning in life (total effect B = –0.284, p < 0.001), while positively associated with loneliness (r = 0.360, p < 0.001). Serial mediation analysis confirmed that hope and loneliness significantly mediated the relationship between childhood adversity and meaning in life. Conclusions: The findings revealed that hope and loneliness were serial mediators in the relationship between childhood traumas and individuals' perceived meaning in life.Öğe Türü:Öğe, Selected genes associated with CVD-related diseases, pathways, and nutrigenetics(Korean Society of Lipid and Atherosclerosis, 2025) Taşdemir, Şeyma Şehadet; Akbulut, GamzeAny dysfunction or obstruction in blood circulation can lead to the development of cardiovascular disease (CVD), which is multifactorial but primarily caused by atherosclerosis. Nutrition is considered as the most significant modifiable environmental factor, with a direct influence on cardiovascular risk mediated by triggering inflammation, oxidative stress, and various physiological, molecular, and biological changes. Despite these well-established mechanisms, targeting nutrition has not led to the expected reduction in CVD mortality rates. This discrepancy is thought to be due to interindividual variability in genetic factors that modulate responses to nutritional interventions. Genetic variants can interact with specific nutrients and dietary components, influencing their effects on cardiovascular health. Advances in nutrigenetics and nutrigenomics which explore nutrient-gene interactions, have led to the development of the concept of personalized nutrition. This approach aims to prevent CVD and other diseases by tailoring dietary treatments to individual genotypes identified through genetic polymorphisms. It is suggested that life expectancy and sustainable healthy living can be enhanced by aligning dietary treatments with specific genetic profiles associated with CVD. Therefore, this review discusses genes linked to CVD and explores how gene-driven differences in dietary responses affect cardiovascular health outcomes.Öğe Türü:Öğe, Phenological stage dependent variations in the chemical composition and cyclooxygenase (COX) inhibitory activities of Origanum dubium Boiss. essential oils(Kahramanmaraş Sütçü İmam Üniversitesi, 2026) Demirbolat, İlkerThis study investigated the essential oil yield, chemical composition, and COX-1/2 inhibitory activity of Origanum dubium during different developmental stages. Essential oil yield increased from 5.53% to 8.37%, peaking at the post-flowering stage. Chemical analysis revealed that oxygenated monoterpenes dominated the oil composition, with carvacrol as the principal component, increasing significantly from 64.4% to 86.9% across growth stages. The anti inflammatory potential was evaluated by measuring COX-1/2 inhibitory activity, using ibuprofen as a positive control (73.53% inhibition). Essential oils exhibited moderate inhibition during vegetative (52.13%) and initial flowering (57.76%) stages, but inhibition notably improved at post-flowering (68.16%), approaching ibuprofen’s efficacy. These findings suggest that the rise in carvacrol concentration correlates with enhanced COX-1/2 inhibitory activity, highlighting the therapeutic potential of O. dubium essential oils as natural anti-inflammatory agents.Öğe Türü:Öğe, Forecasting sustainable development indicators using XGBoost: Evidence from Brazil, Canada, China and India (2005–2023)(World Association for Sustainable Development, 2025) Knio, Mohamad Saad El Dine; Balıkel, Ali ErenPurpose: This paper discusses the potential of machine learning to predict sustainable development indicators, gross domestic product (GDP), employment, and CO₂ emissions in Brazil, Canada, China and India to build a sustainable policy. Design/Methodology/Approach: An annual panel data (2005–2023) was employed to adopt a deductive and explanatory design. XGBoost (Extreme Gradient Boosting) is an algorithm that models nonlinear relationships and identifies important predictors based on macroeconomic, environmental, and policy variables. Findings: XGBoost revealed high accuracy on GDP, and the balance of payments, climate policy, and green investment were some of the important predictors. CO₂ and employment forecasts were less certain because they were overfitted. Originality/Value: The paper identifies the application of machine learning to predict sustainable development, particularly economic modelling. Research Limitations/Implications: There is an implication of overfitting and data limitations, which implies that higher-frequency data and hybrid models are required. Practical Implications: The implication is based on evidence based policymaking in green investment planning and climate policy evaluation.
