İstanbul Kent Üniversitesi Araştırma ve Akademik Performans Sistemi
DSpace@Kent, İstanbul Kent Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
Güncel Gönderiler
Öğe Türü:Öğe, Menarchal status as an indicator of mandibular second molar maturation in female adolescents(Springer Nature, 2026) Altundal, Gizem; Karaca, Ebru; Uzun, Erva; Biren, SibelBackground: Menarchal status is a key pubertal milestone in females, yet its relationship with dental maturation has not been adequately explored using multivariate approaches. This study aimed to evaluate the association between menarchal status and mandibular second molar calcification stages in female adolescents, and to determine whether menarchal status is associated with dental maturation after controlling for chronological age and vertical facial pattern. Methods: This retrospective cross-sectional study included 180 Turkish female patients aged 9-16 years, equally distributed into three groups: pre-menarche (n = 60), early post-menarche (0-1 year, n = 60), and late post-menarche (> 1 year, n = 60). Mandibular second molar calcification was assessed using the Demirjian index (stages D-H). Chronological age across groups was compared using the Kruskal-Wallis test with Dunn post-hoc comparisons. Demirjian stages were analysed using the Kruskal-Wallis test with post-hoc comparisons, Spearman correlation, and ordinal logistic regression analysis controlling for vertical facial pattern (α = 0.05). Results: Demirjian stage distribution differed significantly across menarchal groups (H = 110.49, p < 0.001), with median stages progressing from E to G to H. Menarchal status showed a strong positive correlation with dental maturation (ρ = 0.785, p < 0.001). In multivariate analysis, menarchal status was significantly associated with Demirjian stage (OR = 26.82, 95% CI: 13.66-52.68, p < 0.001); however, the magnitude of this effect partly reflects the equal-group design, and model fit was comparable to that of chronological age (AIC: 377.3 vs. 379.6). Conclusions: Menarchal status is strongly associated with mandibular second molar maturation, with model fit comparable to chronological age. These findings suggest that menarchal history may serve as a clinically accessible, non-invasive biological marker to complement dental maturation assessment in orthodontic treatment planning.Öğe Türü:Öğe, Automated detection of periapical lesions in pediatric panoramic radiographs using YOLOv7: A retrospective internal validation study(Springer Nature, 2026) Shahmaleki, Parmis; Alcan Gezginci, Pelin; Kırelli, Yasin; Yüce, Fatma; Büyük, CansuAim: This study aimed to assess the diagnostic capability of a YOLOv7 deep learning algorithm for the computerized detection of periapical lesions from pediatric panoramic radiographs. Its potential utility as a supportive diagnostic tool and accurate diagnosis in mixed dentition cases was further assessed by comparing the algorithm's performance with the diagnoses made by dental students. Materials and methods: In this study, a total of 408 panoramic radiographs were used, consisting of 333 original images and 75 images generated through feature-based preprocessing expansion. The YOLOv7 model was trained on 302 images, which included 227 original radiographs and 75 images specifically enhanced via grayscale conversion, noise reduction, and edge detection filters to emphasize structural pathological features. A relatively larger set was allocated for testing in order to enhance robustness despite the small sample size. The diagnostic capability of the algorithm and trainees was compared using accuracy, sensitivity, specificity, precision, F1 score, and error rate. Results: YOLOv7 achieved higher diagnostic performance compared with the student group. Its sensitivity (76.1%) was also higher than that of the students (55.2%). The algorithm further demonstrated superior specificity (99.8% vs. 97.3%), precision (99.8% vs. 95.3%), and F1 score (86.4% vs. 69.9%). Conclusion: The findings suggest promising potential in the YOLOv7 algorithm's performance for detecting periapical lesions in deciduous teeth on panoramic radiographs, compared with the diagnostic accuracy of the students.Öğe Türü:Öğe, Evaluation of oxidizable substance interaction associated with orthodontic clear aligners and an acrylic material: A preliminary in vitro study(Galenos Publishing House, 2026) Kurnaz, Merve; Biren, Bora İsmail; Kayhan, Ataberk; Biçim, Gökhan; Biren, Sibel; Güven, YeganeObjective: This study aimed to comparatively evaluate the interactions of oxidizable substances associated with different orthodontic aligner materials using potassium permanganate (KMnO4 ). Methods: In this study, materials from three different clear-aligner manufacturers (SmartTrack, ClearQuartz, and Scheu Dental CA Pro+) and one acrylic block were used. The materials were mechanically fragmented and exposed to KMnO4 , a strong oxidizing agent. Potassium permanganate solutions were prepared at six concentrations (1.24 mM, 0.62 mM, 0.31 mM, 0.16 mM, 0.08 mM, 0.04 mM) to establish a calibration curve (R²=0.9999). Based on this calibration, 0.2 mM and 1 mM solutions were selected for the experimental phase. The color change was evaluated spectrophotometrically at 1, 4, and 24 hours to assess interactions with oxidizable substances. Results: The amount of oxidizable substances interacting with KMnO4 was estimated in mM. Oxidizable substances were detected in all samples (Acrylic Block 0.0723 mM, ClearQuartz 0.0826 mM, Scheu Dental CA Pro+ 0.0584 mM, SmartTrack 0.0271 mM); however, the estimated levels of oxidizable-substance interaction varied among samples. The highest level was observed in ClearQuartz at 24 hours. Conclusion: Orthodontic aligner materials exhibit varying levels of interaction with oxidizable substances, particularly during the first 24 hours. The method may serve as a simple preliminary screening tool. Future studies should investigate the composition of the released substances using more sensitive analytical methods.Öğe Türü:Öğe, Phytochemical characterization and bioactive potential of Stachys germanica L.: LC-MS/MS profiling and multi-target biological activities(Wiley, 2026) İnan, Gözde Gülin; Doğanay, Derya; İnan, Yiğit; Akyüz Çetin, Selin; Neşetoğlu, Neşet; Danış, İbrahim; Mertoğlu, Esra; Özer Ünal, Durişehvar; Zengin, GökhanStachys germanica L. is a member of the Lamiaceae family traditionally recognized for its bioactive secondary metabolites. The present study aimed to investigate the phytochemical composition and biological potential of the 80% ethanolic extract of S. germanica using spectrophotometric assays and liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis. The extract exhibited a high phenolic content (59.80 ± 0.84 mg GAE/g) and flavonoid content (20.50 ± 0.24 mg RE/g), with notable antioxidant activity, particularly in CUPRAC (445.26 ± 6.11 mg TE/g), ABTS (387.12 ± 3.03 mg TE/g), FRAP (360.89 ± 5.19 mg TE/g), and DPPH (333.96 ± 1.61 mg TE/g) assays. Enzyme inhibition assays revealed a selective inhibitory profile, with pro nounced activity against tyrosinase (62.23 ± 0.06 mg KAE/g) and α- glucosidase (1.05 ± 0.24 mmol ACAE/g), suggesting poten tial relevance in dermatological and metabolic applications. Notably, antimicrobial evaluation demonstrated significant activity against Acinetobacter baumannii ATCC 19606 (MIC: 97 μg/mL), highlighting a selective antibacterial effect against a clinically relevant Gram- negative pathogen. LC–MS/MS analysis revealed a chemically diverse metabolite profile largely composed of phe nolic acids and flavonoids, with chlorogenic acid (1024 ± 20.54 μg/g), naringin (196.10 ± 4.65 μg/g), luteolin (82.46 ± 1.88 μg/g), and kaempferol (70.99 ± 1.71 μg/g) identified as the main components. Overall, this study provides a multi- dimensional char acterization of S. germanica, linking its phenolic- rich composition to antioxidant, enzyme- modulating, and selective antimi crobial activities. These findings highlight the potential of S. germanica as a natural source of bioactive compounds for food, nutraceutical, and functional product applications.Öğe Türü:Öğe, Design of plant oil-based cationic hydrogels for protein encapsulation and controlled delivery(Springer Nature, 2026) Maaz, Asmaa; Çaylı, Gökhan; Giray, Betül; Atakol, Arda; Erdem, Ahmet; Çakır Hatır, PınarThe development of sustainable multifunctional hydrogels with antibacterial activity and protein delivery capability is of great interest for biomedical applications. In this study, plant oil-derived cationic hydrogels were developed by UV induced polymerization using acrylated methyl ricinoleate (AMR), a renewable monomer derived from castor oil, and 2-aminoethyl methacrylate (AEMA). The influence of hydrogel composition on morphology, pH-responsive swelling, antibacterial activity, cytocompatibility, and protein encapsulation behavior was investigated. FTIR and SEM analyses confirmed successful hydrogel formation and revealed composition-dependent structural differences. The swelling behav ior was strongly influenced by pH and monomer ratio. The hydrogels exhibited significant antibacterial activity against Escherichia coli and Staphylococcus aureus while maintaining good cytocompatibility toward human umbilical vein endo thelial (HUVEC) cells, with cell viability exceeding 80%. Bovine serum albumin (BSA) was used as a model protein to evaluate encapsulation and release properties. Protein encapsulation efficiency was found to depend strongly on crosslink ing density, with lower crosslinking ratios leading to enhanced loading. Overall, the results demonstrate that combining a renewable plant oil-derived monomer with a cationic component enables the fabrication of sustainable hydrogels with tunable physicochemical and biological properties, highlighting their potential for wound healing and localized protein delivery applications.
