İstanbul Kent Üniversitesi Araştırma ve Akademik Performans Sistemi
DSpace@Kent, İstanbul Kent Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
Güncel Gönderiler
Öğe Türü:Öğe, A retrospective study of selective dorsal neurectomy for lifelong premature ejaculation: erectile and ejaculatory functions, sensory correlation, and safety evaluation(Wiley, 2025) Başağa, Yaşar; Albayrak, Ahmet Tevfik; Sökmen, Doğukan; Sertkaya, ZülfüIntroduction: Premature ejaculation (PE) is a common male sexual dysfunction and a subset of patients with lifelong PE remainunresponsive to pharmacologic and behavioral therapies. Although selective dorsal neurectomy (SDN) is practiced in certainregions, its safety and efficacy remain underexplored in Western guidelines.Objective: The main aim of this study is to evaluate the clinical outcomes, sensory changes, and safety profile of SDN in patientswith lifelong PE who failed conventional treatments.Methods: In this retrospective cohort study, we reviewed 82 patients with lifelong PE who underwent SDN between January andOctober 2024. Patients were selected based on strict clinical criteria, including failed response to medical therapy and evidence ofpenile hypersensitivity, which was objectively assessed using a biothesiometer. SDN involved preserving at least one dorsal penilenerve <1 mm in each of the three anatomical zones. Pre and postoperative assessments included intravaginal ejaculatory latencytime (IELT), the International Index of Erectile Function-5 (IIEF-5), the PE diagnostic tool (PEDT), and biothesiometry scores.Results: At 6 months postoperatively, mean IELT increased by 241.04 Æ 134.02 s (559.12%, p <0:001), PEDT scores decreased by6.98 Æ 1.66 points (48.07%, p <0:001), and IIEF-5 improved by 1.51 Æ 0.79 points (6.63%, p <0:001). A strong negative correlationwas observed between preoperative sensory thresholds and postoperative improvement in sensory thresholds (Spearman r = −0.83to −0.70, all p <0:001). No major complications, including glans numbness or anorgasmia, were reported.Conclusion: SDN appears to be a safe and effective surgical option for selected patients with lifelong PE who are unresponsive toconservative treatments. The procedure resulted in significant improvements in ejaculatory control with minimal risk whenperformed using a nerve-preserving approach.Öğe Türü:Öğe, Synthesis and biological evaluation of modified peptide derivatives targeting the SARS-CoV-2 nsp3 macrodomain (Mac1) replication domain(ACS Publications, 2026) Özmen, Özge; Oruçoğlu, Betül; Dingiş Birgül, Serap İpek; Öztürk Civelek, Dilek; Gül, Şeref; Akdemir, Atilla; Sönmez, Fatih; Zengin Kurt, BelmaModified peptide derivatives (D1−D15) containing hydrophobic (phenylalanine and tryptophan) and positively charged (histidine) amino acid residues, were designed and synthesized. The cytotoxicity of the compounds was evaluated in healthy (CCD1079Sk) cell lines, revealing no significant cytotoxic effects and indicating favorable safety profiles. Molecular modeling studies were performed for all compounds and indicated that compounds D13, D14, and D15 form favorable binding interactions with the Nsp3 macrodomain 1 (Mac1) active site. The affinity of these compounds is expected to be moderate to high, although lower than that of ADP ribose. Subsequent bioactivity assays, performed using a cell-based SARS-CoV-2 replicon system, revealed that compound D15 displays the most potent inhibition of viral replication (IC50 = 22.2 μM (95% CI: 15.4−35.7 μM)), while compound D14 shows the second most potent inhibitory activity (IC50 = 61.2 μM (95% CI: 39.2− 143.9 μM)). Considering these results, it has been shown that compounds with a histidine side chain exhibit higher biological activity, suggesting a structure−activity relationship driven by positively charged residues.Öğe Türü:Öğe, Associations between physical activity, body dissatisfaction, and mindful eating in Turkish adults(MDPI, 2026) Ermiş, Dilay; Turgut Yaman, Rana; Akgül, Ece; İçelli, Asu Şevval; İşeri, Ceren; Öztürk, Elif; Kızıl, Merve; Şahin, Sude Melis; Çamlıbel, Beyzanur; Akbulut, GamzeObjective: This cross-sectional study examined the associations among physical activity, body dissatisfaction, and mindful eating in adults, while accounting for the influence of demographic and socioeconomic factors. Methods: A total of 9838 adults (60.6% women, 39.4% men; mean age 36.3 ± 16.0 years) were included in the study using a convenience sampling method (women: 34.4 ± 15.1 years; men: 39.2 ± 16.9 years). Physical activity was measured with the International Physical Activity Questionnaire-Short Form (IPAQ-SF), body dissatisfaction was measured with the Stunkard Figure Rating Scale (FRS), and mind ful eating was assessed with the Four Facet Mindful Eating Scale (FFaMES). Spearman correlation, Kruskal–Wallis, and hierarchical regression analyses were conducted. Re sults: Physical activity showed weak but statistically significant positive correlations with body dissatisfaction and mindful eating, while no association was observed between body dissatisfaction and mindful eating. After adjustment for demographic and socioeconomic variables, body dissatisfaction and mindful eating remained associated with physical activ ity, although the explained variance was small. Participants with moderate physical activity levels had higher mindful eating scores than those with low activity. Conclusions: The findings indicate weak associations among physical activity, body dissatisfaction, and mindful eating among adults. Although statistically significant, these associations were small, suggesting that these psychosocial factors represent only a limited component of the broader determinants of physical activity behaviour.Öğe Türü:Öğe, Türk Mahkemelerinin bilimsel görüşlerden yararlanması hakkında bazı değerlendirmeler(Çukurova Üniversitesi, 2026) Pehlivanoğlu, Murat Can; Özcan, Mustafa Emin4721 sayılı Türk Medeni Kanunu m. 1(3) uyarınca “hâkim, karar verirken bilimsel görüşlerden ve yargı kararlarından yararlanır”. Bununla beraber, uygulamada hâkimin bilimsel görüşlerden ve dolayısıyla öğretiden hangi ölçüde yararlandığı bilinmemektedir. Oysa mahkemelerin bilimsel görüşlerden faydalanma ölçüsünün tespiti birçok açıdan önem taşımaktadır. Bu anlayışla, eldeki çalışmada, mahkeme kararlarını tarayan bir veri tabanı yoluyla hazırlanan veri seti üzerinden bir kısım güncel mahkeme kararı incelenmiştir. Bu kararlarda atıf yapılan bilimsel görüşler tespit edilmiş, sınıflandırılmış ve değerlendirilmiştir. Çalışmanın sonucunda Türk hukuku uygulamasında bilimsel görüşler içerisinden en çok “yorumlayıcı” nitelikte olanlardan faydalanıldığı ve yine en çok kitap türünde somutlaşan bilimsel görüşlere ilgi gösterildiği tespit edilmiştir. Bununla beraber, atıflara yansıdığı ölçüde, Türk hukuku uygulamasında bilimsel görüşlerden yararlanma oranının düşük olduğu anlaşılmıştır.Öğe Türü:Öğe, Preventing Bakri balloon puncture during cesarean section in placenta previa: Fundal fixation Temur technique(Springer Nature, 2025) Temur, Muzaffer; Karaşin, Süleyman SerkanPlacenta previa is a major risk factor for obstetric hemorrhage. Bakri balloon tamponade (BBT) is a well established uterine-sparing method, but balloon puncture during uterine closure may compromise its effectiveness. We present a fundal fixation technique, a simple modification involving temporary fundal fixation of the balloon catheter to displace it away from the hysterotomy site during closure. This technical report outlines the method and summarizes the outcomes from four cases of placenta previa that were managed successfully. This fundal fixation technique is a safe and effective method for minimizing balloon puncture risk during cesarean sections.
