İstanbul Kent Üniversitesi Research and Academic Performance System
DSpace@Kent is an integrated information system that unifies the monitoring, analysis and reporting of scientific research and academic performance at İstanbul Kent University.
Recent Submissions
Item type:Item, Dietary regulation of intestinal stem cell function: Nutrient-sensing, microbiota-mediated, and regenerative mechanisms from a dietetic perspective(MDPI, 2026) Akbaş, Elif; Gürgen, Beyza Nur; Akgül, Ece; Günay, Esra; Tok, Burçak; Özduran, Ecem; Ersoy Yalçın, Saliha; Cihan Çağatay, Sena; Aksoy, Zeynep Büşra; Ağagündüz, Duygu; Raposa, BenceThe intestinal epithelium is a dynamic tissue renewed by intestinal stem cells (ISCs) within the crypt niche. ISC behavior is regulated not only by intrinsic genetic programs but also by dietary composition, nutrient availability, microbial metabolites, and feeding rhythms. This narrative review synthesizes mechanisms through which diet influences ISC self-renewal, proliferation, differentiation, metabolic programming, and regenerative capacity. Dietary patterns exert context-dependent effects: caloric restriction, fasting, and structured feeding–fasting cycles may enhance epithelial regeneration through nutrient-sensing pathways, mitochondrial adaptation, and circadian regulation, whereas Western-type and high-fat diets may promote niche remodeling, inflammation, metabolic reprogramming, and tumorigenic risk. Macronutrients regulate ISC fate through carbohydrate metabolism, amino acid sensing, fatty acid oxidation, and lipid-derived signaling molecules. Micronutrients, including vitamins A, D, and B and minerals such as iron, zinc, selenium, and magnesium, contribute to epithelial differentiation, redox balance, and barrier integrity. Phytochemicals may modulate ISC function through Wnt/β-catenin, Nrf2, SIRT1, and epigenetic pathways or by stabilizing the epithelial microenvironment. The gut microbiota mediates diet–ISC interactions via short-chain fatty acids, bile acids, indole derivatives, and other metabolites. However, human evidence remains limited, and studies integrating human organoids, single-cell analyses, metabolomics, and chrononutrition are needed to inform personalized nutritional strategies for intestinal health.Item type:Item, Tip 2 diyabetli bireylerde beslenme alışkanlıkları ve kan parametrelerinin değerlendirilmesi(Erciyes Üniversitesi, 2026) Toprak, Muhammet Sait; Kale, Selin; Dertop, CansuBu araştırma, İstanbul ilindeki özel bir hastanenin Dahiliye Polikliniği’ne başvuran tip 2 diyabetli yetişkin bireyler ile sağlıklı bireylerin beslenme alışkanlıklarını ve kan parametrelerini karşılaştırmalı olarak değerlendirmek amacıyla yapıldı. Araştırma analitik kesitsel bir çalışma olarak gerçekleştirildi ve tip 2 diyabet grubuna 90 birey, sağlıklı bireyler grubuna 90 birey dahil edildi. “Hasta Tanıtım Formu” ve “Beslenme Alışkanlıkları Anketi” kullanılarak beslenme alışkanlıkları ve biyokimyasal parametreleri değerlendirildi. Nicel verilerin analizinde bağımsız örneklem t testi, nitel verilerin karşılaştırılmasında Pearson‐ki‐kare testi ve Fisher's exact testi kullanıldı. Sonuçlar; %95 güven aralığında, anlamlılık ise p<0.05 altında değerlendirildi. Tip 2 diyabet tanısı alan bireylerde; beden kütle indeksi, bel çevresi, bel/kalça oranı, açlık kan glukozu, Hemoglobin A1c, Düşük Yoğunluklu Lipoprotein, trigliserit ve total kolesterol kontrol grubuna göre istatistiksel olarak anlamlı düzeyde daha yüksek (p<0.001), Yüksek Yoğunluklu Lipoprotein ise daha düşük (p=0.010) bulunmuştur. Ailede diyabet öyküsü varlığı (%83.3 ve %37.8), ana öğün (%76.6’ya %26.7) ve ara öğün (%73.3’e %57.8) atlama oranları tip 2 diyabet grubunda istatistiksel olarak anlamlı düzeyde daha fazlaydı. Diyabet hastalarının davranış değişikliğine teşvik edilmesiyle birlikte farkındalıklarının arttırılması sonucunda doğru beslenme ve aktif fiziksel aktiviteye sahip olmaları yaşam kalitelerini artıracaktır. Bu temeli hazırlamak için toplumun her bireyinin küçük yaşlardan itibaren, hastalık başlamadan önce eğitim alması son derece önemlidir.Item type:Item, Resource scarcity and failed mediation: Unpacking the Kyrgyz-Tajik territorial dispute(Ozan Örmeci, 2026) Abdurahimova, Maftunahon; Özel, MesutThe territorial dispute between Kyrgyzstan and Tajikistan, centered in the Ferghana Valley, remains a critical flashpoint for instability in Central Asia. This article argues that the conflict is perpetuated by a confluence of three factors: the legacy of arbitrary Soviet-era border demarcations, which created volatile enclaves like Vorukh; intense competition over scarce water and pastureland resources, vital to both nations’ agrarian economies; and the political exploitation of ethnonationalist rhetoric by elites. Using a qualitative case study methodology and documents and discourse analysis of primary sources (government statements, international reports) and secondary literature, this research evaluates the effectiveness of international mediation. The findings indicate that efforts by the United Nations (UN) and the Organization for Security and Co-operation in Europe (OSCE) are severely limited, earning a “Poor” to “Fair” effectiveness rating due to a lack of enforcement mechanisms and the primacy of national sovereignty. Consequently, their interventions fail to address the conflict’s root causes. The article concludes that a sustainable resolution requires a paradigm shift in international policy, moving from high-level diplomacy towards supporting local resource-sharing agreements, investing in joint infrastructure, and fostering track-II diplomacy to counter nationalist narratives.Item type:Item, An integrative nature-based planning model for sustainable and resilient environments(Springer Nature, 2026) Çınar, Hande Sanem; Yılmazsoy, BurakDespite increasing policy recognition of Nature-based Solutions (NbS), a persistent gap remains between conceptual sustainability frameworks and reproducible, perfor mance-based planning applications supported by spatial modeling and ecosystem service quantification. This study addresses this gap by developing a spatially explicit NbS planning and evaluation framework for the Shenks Property along the Severn River within the Chesapeake Bay watershed, Virginia, USA. The research integrates GIS-based hydrological modeling, ecosystem-service assessment using the InVEST platform, and resilience evaluation under NOAA 2050 intermediate sea-level rise projections.Multiple spatial datasets, including land-use/land-cover classifications, LiDAR-derived elevation models, soil characteristics, biodiversity inventories, and tidal observations, were analyzed within an integrated analytical workflow. Results indicate measurable ecological and hydrological improvements under NbS-based scenarios. Predictive simulations demonstrate an approximately 40% (± 5%) reduction in annual surface runoff and an approximately 20 m retraction of projected flood boundaries under future sea-level rise conditions. Carbon-storage capacity increased by 18–24%, while habitat-quality index values improved by 15–22% within rehabilitated wetland zones. Increased vegetation density additionally contributed to localized microclimatic cooling of approximately 2–3 °C. The findings demonstrate that NbS can simultane ously support climate adaptation, ecological restoration, and long-term spatial resil ience while potentially reducing maintenance demands relative to conventional gray infrastructure systems. Methodologically, the study advances the operationalization of NbS by integrating ecosystem-service modeling, hydrological simulations, and adap tive spatial planning into a transferable performance-based planning framework. How ever, while the study offers robust predictive insights, its findings are based on mode ling and scenario-based simulations. Therefore, long-term post-occupancy monitoring is essential to validate ecological performance and system resilience.Item type:Item, Bot faaliyetleri yoluyla haksız rekabet ve elektronik ticaret platformunun bot saldırılarından sorumluluğu(Aristo Yayınevi, 2026) Pehlivanoğlu, Murat CanBu çalışmada bot saldırılarının işletmeler arasındaki rekabeti bozan bir haksız rekabet eylemi olarak değerlendirilip değerlendirilemeyeceği incelenmekte ve yine bu çerçevede üzerinden saldırı gerçekleştirilen elektronik ticaret platformunun hukuki sorumluluğuna değinilmektedir.
