İstanbul Kent Üniversitesi Araştırma ve Akademik Performans Sistemi
DSpace@Kent, İstanbul Kent Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
Güncel Gönderiler
Öğe Türü:Öğe, Design of plant oil-based cationic hydrogels for protein encapsulation and controlled delivery(Springer Nature, 2026) Maaz, Asmaa; Çaylı, Gökhan; Giray, Betül; Atakol, Arda; Erdem, Ahmet; Çakır Hatır, PınarThe development of sustainable multifunctional hydrogels with antibacterial activity and protein delivery capability is of great interest for biomedical applications. In this study, plant oil-derived cationic hydrogels were developed by UV induced polymerization using acrylated methyl ricinoleate (AMR), a renewable monomer derived from castor oil, and 2-aminoethyl methacrylate (AEMA). The influence of hydrogel composition on morphology, pH-responsive swelling, antibacterial activity, cytocompatibility, and protein encapsulation behavior was investigated. FTIR and SEM analyses confirmed successful hydrogel formation and revealed composition-dependent structural differences. The swelling behav ior was strongly influenced by pH and monomer ratio. The hydrogels exhibited significant antibacterial activity against Escherichia coli and Staphylococcus aureus while maintaining good cytocompatibility toward human umbilical vein endo thelial (HUVEC) cells, with cell viability exceeding 80%. Bovine serum albumin (BSA) was used as a model protein to evaluate encapsulation and release properties. Protein encapsulation efficiency was found to depend strongly on crosslink ing density, with lower crosslinking ratios leading to enhanced loading. Overall, the results demonstrate that combining a renewable plant oil-derived monomer with a cationic component enables the fabrication of sustainable hydrogels with tunable physicochemical and biological properties, highlighting their potential for wound healing and localized protein delivery applications.Öğe Türü:Öğe, Assessing metabolic and reproductive consequences of prenatal paracetamol exposure in female CD1 mice(Wiley, 2026) Entezari, Bita; Bozdağ, Deniz; İnce Ergüç, Elif; Buhur, Aylin; Tomruk, Cansın Şirin; Sabuncuoğlu, Suna; Yavaşoğlu, Altuğ; Gürer Orhan, HandeParacetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/ metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long- term metabolic and reproductive consequences linked to intrauterine paracetamol exposure. Pregnant dams were administered paracetamol at three dose levels (Cmax/10, Cmax, and Cmax × 10) during a critical window of organogenesis (gestational days 7.5–16.5). Offspring were monitored until 17 weeks of age to assess growth, glucose homeostasis, lipidomic profiles, and ovarian his tology. Prenatal exposure did not significantly affect total body weight but induced a dose- dependent increase in peritoneal adipose tissue mass, particularly in the Cmax × 10 group. Metabolic assessments revealed impaired glucose tolerance in the Cmax/10 group and increased insulin sensitivity across all dose groups. Adipose tissue gene expression analysis demonstrated upregulation of adipogenic markers (Pparγ, Lpl, Fasn), while untargeted lipidomics revealed consistent dysregulation of lipid species, including lysophosphatidylcholines (LPCs), phosphatidylcholines (PCs), sphingomyelins (SMs), and triacylglycerols (TGs), indicating altered lipid storage and inflammatory signaling. Histological evaluation showed a marked reduction in total follicle number and increased follicular atresia following paracetamol exposure. Degenerative changes in oocytes and granulosa cells were observed, and multi- oocyte follicles (MOFs) were detected exclusively in the Cmax/10. Collectively, these findings demonstrate that intrauterine paracetamol exposure induces persistent developmental reprogramming in female off spring, characterized by visceral adiposity, disrupted lipid homeostasis, and depletion of the ovarian reserve. Notably, several endpoints exhibited non- monotonic dose–response relationships, underscoring the sensitivity of developing systems to even subtherapeutic paracetamol exposure.Öğe Türü:Öğe, Power, discourse, and governance: An analysis of Türkiye’s long horizon integrated maritime surveillance system(Milli Savunma Üniversitesi, 2026) Özel, MesutThis article challenges the paradigmatic exclusivity of analyses of contemporary security technologies within International Relations and Security Studies. It develops and applies an integrated theoretical framework—synthesizing realist, securitization, and critical security studies perspectives—to examine Türkiye’s Long Horizon Integrated Maritime Surveillance System (LHIMSS). The study demonstrates that LHIMSS functions simultaneously as a realist instrument for asymmetric balancing, a securitized project legitimized by the Blue Homeland doctrine, and a critical governance vehicle that expands state control through a militarized “White Picture.” By revealing the recursive interplay among material capabilities, discursive threat-making, and transformative governance, the integrated approach provides a holistic understanding of how middle powers navigate contested sovereignty and hybrid security. The findings challenge IR scholarship to abandon rigid theoretical compartments and develop multi-causal models that capture the material, discursive, and biopolitical dimensions of 21st-century security.Öğe Türü:Öğe, Chapter 4 - The thermogenic roles of bioactive compounds: A comprehensive bibliometric review(Elsevier, 2026) Karakaya, Zeynep Ercan; Turgut, Rana; Günalan, ElifThe current review aims to describe the physiological mechanisms of thermogenic bioactive substances at the molecular level and to analyze the publications in the Scopus database using VOSviewer. The stimulation of thermogenesis by external factors, such as diet, is a multifaceted approach with significant potential to combat obesity and its associated metabolic complications. This understanding has led to numerous studies that have defined the thermogenic role of various bioactive compounds in metabolic health. Bibliometric analysis of these studies highlights the activation of brown adipose tissue (BAT), mitochondrial biogenesis, and stimulation of browning, which are the cornerstone mechanisms underlying the action of these compounds. However, each bioactive compound regulates distinct genes and signaling pathways, resulting in varied physiological responses. The findings provide a strong basis for the anti-obesity effects of thermogenic bioactive compounds. Many clinical studies can be designed using various doses, pharmaceutical routes, and forms of thermogenic compounds to treat obesity. However, phytochemical treatment interventions that include BAT activation must be closely monitored and managed due to the cardiovascular risks.Öğe Türü:Öğe, Integrated multiscalar approach based on space syntax analysis: Case study of a UNESCO candidate slow city in Mudurnu, Turkey(MDPI, 2026) Kırkık Aydemir, Kıymet Pınar; Karakuş, Nihat; Yılmazsoy, Burak Kaan; Aydın, Aslı İremPedestrian accessibility is a key determinant of spatial experience, cultural heritage visibil ity, and urban integration in historical cities. This study analyzes pedestrian accessibility in Mudurnu—aUNESCOTentative List site and Cittaslow—using a multi-scale, integrated space syntax approach. By combining axial and segment analyses, statistical validations, and Kernel Density Estimation (KDE), the research examines the relationship between urban morphology and pedestrian movement potential. Spatial data developed through open-access maps and field validations were analyzed via depthmapX 0.8 and QGIS 3.40.11 software. Syntactic indicators—integration, connectivity, choice, and intelligibility—were calculated at global and local scales, alongside synergy and points of interest (POI) correla tions. The results indicate that mobility is concentrated along the north–south Bolu–Yıldırım Beyazıt–Ankara axis, while secondary networks in traditional residential areas remain poorly integrated. Low intelligibility (R2 = 0.06) indicates local spatial configurations provide insufficient cognitive guidance, and moderate synergy (R2 = 0.33) suggests partial harmony between scales. Segment and KDE results highlight concentrated mobility, with secondary networks emerging after logarithmic transformation. Consequently, Mudurnu exhibits fragmented accessibility and low legibility. These findings demonstrate that multi scale space syntax analysis is an effective decision-support tool for pedestrian-oriented planning and sustainable urban design in historical cities.
