İstanbul Kent Üniversitesi Araştırma ve Akademik Performans Sistemi
DSpace@Kent, İstanbul Kent Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
Güncel Gönderiler
Öğe Türü:Öğe, The letrozole use in reproductive medicine: Beyond aromatase inhibition - a comprehensive review(Galenos Publishing House, 2026) Aydın, Gerçek; Hatırnaz, Şafak; Saynur Hatırnaz, Ebru; Çetinkaya, Mehmet Bilge; Akdeniz, Muhterem; Dokuzeylül Güngör, Nur; Güler, Oğuz; Merdanoğlu, Merdan Ali; Uzun, Asiye; Eroğlu, Semra; Tosun, Önder; Bahadırlı, Ali; Yurtçu, Engin; Keyif, Betül; Güvey, Huri; Gürkan, Naziye; Karlı, Pervin; Yılmaz, Zehra; Baldini, Giorgio Maria; Tavuz, Ali İhsan; Sparic, Radmila; Tabakova, Nikoleta; Tinelli, Andrea; Cao, Mingju; Tan, Seang Lin; Hatırnaz, Oğuz; Dahan, MichaelLetrozole and other aromatase inhibitors are increasingly recognized as first-line ovulation induction (OI) medications, offering an efficient and physiologic approach to ovarian stimulation that enhances outcomes in reproductive medicine. By selectively inhibiting aromatase and maintaining lower peripheral estrogen levels, letrozole supports mono- or bi-follicular development while reducing the risk of supraphysiologic estradiol exposure seen with traditional gonadotropin regimens. These pharmacological characteristics have contributed to its expanding use not only in OI but also in various assisted reproductive technologies. To evaluate the clinical benefits, effectiveness, and safety of using letrozole in in vitro fertilization (IVF), in vitro maturation (IVM), and OI, with particular attention to reproductive outcomes, ovarian response, endometrial effects, cycle characteristics, and treatment-related adverse events. A comprehensive systematic search covering the period from December 2000 to November 2025 was conducted across major electronic databases including PubMed, Embase, the Cochrane Library, and Google Scholar. The search strategy incorporated predefined keywords related to letrozole, aromatase inhibition, OI, IVF, and IVM. Studies involving randomized controlled trials, observational cohorts, and meta analyses were included, while non-clinical and non-reproductive data were excluded. Relevant outcomes were extracted and synthesized qualitatively. Letrozole demonstrates broad clinical utility in reproductive medicine, spanning assisted reproductive techniques, ovarian stimulation strategies, and the management of ovarian hyperstimulation syndrome risk, ectopic pregnancy, and endometriosis-related infertility. Its targeted estrogen suppression, cost-effectiveness, and favorable safety profile make it a valuable component of individualized treatment protocols. Nonetheless, further high-quality research is required to refine optimal dosing strategies, identify ideal patient populations, and clarify long-term reproductive and obstetric safety.Öğe Türü:Öğe, Clinical relevance of postoperative biomarkers in pediatric endourology: Is procalcitonin telling the truth?(Elsevier, 2026) Genç, Yunus Emre; Arslan, Faruk; Seyidov, Mirgasim; Özkan, Onur Can; Şener, Tarık Emre; Tanıdır, Yılören; Yücel, Selçuk; Cam, Kamil; Tarcan, Tufan; Şekerci, Çağrı AkınPurpose: Although acute phase reactants (APRs) are widely used in the postoperative period in various procedures, no clear recommendations exist for their clinical use in pediatric stone disease. We aimed to evaluate the clinical utility of APRs to diagnose UTI and urosepsis in pediatric endourological post operative courses. Methods: This case-control study retrospectively analyzed pediatric patients who underwent endourological intervention for stone disease in a single, tertiary referral center. Serum levels of white blood cell count (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were assessed on post operative days (POD)- 0 and 1. Risk factors and cut-off values of APRs for infectious complications were assessed with multivariate and ROC analyses. Results: We included 223 children, in whom UTI developed in 14 % and urosepsis in 5 % of patients. Leucocyte esterase activity in preoperative urine analysis, total diameter of stones and the duration of surgery were found to differ in patients with UTI, whereas in patients with urosepsis, a difference was only observed in the duration of surgery among parameters. The highest area under the curve was reached with POD-1 PCT, in detecting UTI (AUC: 0.778) with a cut-off value of 0.29 μg/L and urosepsis (AUC: 0.901) with a cut-off value of 0.62 μg/L. Conclusion: Patients with a prolonged duration of surgery are at risk for infectious complications. To monitor these high-risk patients, PCT is highly specific in serum levels higher than 0.29 μg/L for UTI and 0.62 μg/L for urosepsis. Multicentric and prospective studies are needed to validate and confirm these results.Öğe Türü:Öğe, Some biological activities of ethanol extract of Amaranthus lividus L. seeds and isolation of the lectin from the crude extract(Istanbul University Press, 2025) Üğüden, Ayhan; Özsoy, Nurten; Can, AyşeBackground and Aims: Amaranth is a gluten-free pseudocereal with nutraceutical properties. The aim of this study was to evaluate the antioxidant, anti-cholinergic and cyclooxygenase (COX) inhibitory effects of the ethanol extract and isolate the lectin from the crude extract prepared from seeds of Amaranthus lividus L. Methods: The dried powdered seeds were extracted with ethanol using a Soxhlet apparatus. The antioxidant activity of the ethanol extract was estimated by DPPH, ABTS and superoxide radical scavenging activities, as well as the Trolox equivalent antioxidant capacity (TEAC) and Ferric-Reducing Antioxidant Power (FRAP). The total phenolic compound content was determined using the Folin-Ciocalteu reagent. The extract was screened for its acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities using Ellman’s method. The ability of the extracts to inhibit COX-1 and COX-2 was determined by enzyme immunoassay. The lectin was purified from the crude extract by a two-step procedure of 50% ammonium sulphate precipitation and affinity chromatography on CNBr-activated Sepharose 4B, using ovalbumin as a ligand. The molecular weight was determined using SDS-PAGE. Results: Results showed that the extract possesses in vitro antioxidant, AChE, BuChE, COX-1 and COX-2 inhibitory activities, suggesting that it may provide treatment options for oxidative stress mediated diseases like Alzheimer’s, inflammatory and cancer diseases. The crude extract of the A. lividus seeds was found to contain lectin, evident by hemagglutination. The lectin was purified to homogeneity approximately 16-fold over the crude extract. It was determined to be a homodimer, and the molecular weight of the monomer corresponded to 34 kDa. Conclusion: The results showed that the seeds of A. lividus contain valuable ingredients such as phenolic compounds and lectin that are beneficial for health.Öğe Türü:Öğe, Risk factors for nonunion of ulnar styloid fractures associated with distal radius fractures(Prusa Medical Publishing, 2025) Kaya, Emre; Akdemir, Nurtaç Alper; Geçer, Ali; Konukoğlu, LeventObjectives: A major complication of ulnar styloid fractures (USFs) associated with displaced distal radius fractures (DRFs) is nonunion, which can result in pain and instability of the distal radioulnar joint (DRUJ). This study aimed to identify the risk factors influencing the healing of USFs in cases of displaced DRFs, when treated using different methods - either surgically with plate-screw fixation, or conservatively with closed re duction and a plaster cast. Methods: A total of 41 patients with USFs associated with DRFs, treated either surgically or conservatively, were retrospectively evaluated. Fractures were classified based on the treatment modality (surgical/conserva tive), demographic data, and radiographic characteristics. The Fernandez classification system was used to cat egorize DRFs. USF displacement was stratified into two groups: displacement >2 mm and <2 mm. Union and nonunion rates were compared across all parameters. Results: Of the 41 cases included, 12 DRFs were managed surgically with plate-screw fixation, while 29 were treated conservatively with closed reduction and casting. Union was achieved in 35 cases, whereas nonunion was observed in 6. A statistically significant correlation was found between USF displacement >2 mm and nonunion. No significant association was observed between nonunion and other variables, including treatment modality, age, sex, laterality, or fracture classification. Conclusions: The development of nonunion in USFs accompanying DRFs is not significantly influenced by treatment modality, age, sex, fracture classification, or side of involvement. However, a displacement of the USF greater than 2 mm is associated with a significantly increased risk of nonunion.Öğe Türü:Öğe, Turkish validity and reliability of the systems thinking scale(Hacettepe University, 2025) Açıkgöz, GizemAim: The aim of the study is to evaluate the validity and reliability of the Turkish version of the System Thinking Scale. Materiel and Methods: The methodological study was conducted with 369 health professionals working in Istanbul between February - July 2024. The data were collected with descriptive information form and the Systems Thinking Scale. SPSS 24.0 program was used to evaluate the data, and the validity and reliability tests were conducted. Results: The Kaiser Meyer Olkin coefficient of the scale was found 0.87, and the scale was suitable for factor analysis. The factor loadings of the items varied between 0.50 and 0.89, and the total variance explained by the scale was 55.48%. The scale consisted of a single dimension. The fit indices of the scale were χ²/df = 4.68, RMSEA = 0.09, NFI = 0.90, NNFI = 0.90, SRMR = 0.08, and CFI = 0.95. The AVE was 0.535, CR was 0.957, ICC was 0.99, and α was 0.95. Conclusions: The Turkish version of the system thinking scale consists 20 items and a single dimension. The scale, which demonstrated good psychometric properties in Turkish, can be used to evaluate systems thinking within health systems. Implication for nursing practice/management or policy: It is thought that the use of the scale will create awareness for ensuring system security in health systems and contribute to the orientation of considering the system as a whole.
