DSpace Repository

İstanbul Kent Üniversitesi Research and Academic Performance System

DSpace@Kent is an integrated information system that unifies the monitoring, analysis and reporting of scientific research and academic performance at İstanbul Kent University.

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Recent Submissions

Delta-9-tetrahydrocannabinol ameliorates oxidative stress, mitochondrial redox state, and neuroinflammation induced by high-fructose diet
(Springer Nature, 2026)
Toprak, Muhammet Sait
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Coşkun Yazıcı, Zeynep Mine
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Yanar, Karolin
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Bolkent, Sema
This study investigates the effects of a high-fructose diet (HFD) on brain oxidative stress, mitochondrial redox state, and pro-inflammatory cytokine expression, and specifically evaluates whether delta-9-tetrahydrocannabinol (THC) attenuates these HFD-induced changes. Thirty-two Sprague–Dawley rats were divided into four groups: Control, HFD (10% fructose in drinking water for 12 weeks), THC (1.5 mg/kg daily for the last 4 weeks), and HFD + THC (HFD for 12 weeks with THC co-administration during the final 4 weeks). Biochemical biomarkers (AOPP, DT, KYN, MDA, AGE, T-SH, NADH, FAD, serotonin, insulin) and mRNA expression levels of inflammation-related genes (IL-6, IL-1β, TNF-α, NF-κB) were analyzed in brain tissues. The HFD significantly increased levels of protein oxidation (AOPP, DT, KYN, AGE); lipid peroxidation (MDA); and NADH and FAD fluorescence whilst decreasing total thiol (T-SH) content. HFD also increased the mRNA expression of all inflammatory markers examined. In contrast, THC treatment significantly reduced oxidative damage and NADH and FAD fluorescence and reduced the relative mRNA expression of the investigated inflammation-related genes. Strong positive correlations were observed between pro-inflammatory cytokine mRNA expression and oxidative stress markers. HFD causes significant biochemical and molecular damage to the brain. THC administration was associated with a significant attenuation of HFD-induced oxidative stress, mitochondrial redox state, and pro-inflammatory cytokine expression, suggesting that it may mitigate diet-associated neurochemical perturbations.
Grand strategy in the United States and China
(BİDGE Yayınları, 2026)
Abdollahi, Narjes
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Özel, Mesut
This chapter examines how grand strategy is conceptualized and implemented in the United States and China, focusing on the relationship between regime type and strategic continuity. Drawing on the distinction between grand plans, grand principles, and grand behavior, it traces major shifts in U.S. strategy from hemispheric priorities to Cold War containment and post-9/11 interventionism and follows Chinese strategic developments from Mao Zedong through reform and opening-up and subsequent multilateral engagement. It then compares the two states' approaches to threat perception, strategic transparency, domestic legitimacy, and the instruments used to shape international order. The chapter argues that electoral turnover and institutional checks in the United States generate more visible adjustments in strategic execution, while China's one-party structure supports greater continuity in overarching objectives, notwithstanding tactical change. It concludes by identifying the limits of strategy documents as predictors of state behavior in both systems.
NATO’s Black Sea presence: Strategy, maritime adaptation, and Montreux
(Eğitim Yayınevi, 2026)
Özel, Mesut
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Effects of red and purple berries on glucose metabolism, insulin resistance, and type 2 diabetes: Bibliometric analysis
(Türkiye Klinikleri, 2026)
Başören, İrem
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Ermiş, Dilay
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Çelik, Zehra Margot
Objective: This study aims to provide a comprehensive bibliometric analysis of the scientific literature on the effects of red and purple berries on glucose metabolism, insulin resistance, and Type 2 diabetes between 2016 and 2025. Material and Methods: Publications indexed in the Web of Science Core Collection and Scopus databases were retrieved using a predefined search strategy. Only English-language original research articles and review papers were included, while conference proceedings, early access papers, and non-relevant studies were excluded. After removing duplicates, a total of 1,726 publications were analyzed using the Bibliometrix R package and Biblioshiny, with additional visualization support from Microsoft Excel. Results: The findings demonstrated a steady increase in scientific output, with an annual growth rate of 5.91% across 598 sources. A total of 7,569 authors contributed to the literature, with a high level of collaborative research. The most productive journals included Nutrients, Journal of Functional Foods, and Food & Function. Keyword analysis revealed that diabetes, obesity, inflammation, and polyphenols were dominant research themes, while emerging topics included gut microbiota and precision nutrition. Thematic analysis indicated a growing focus on mechanistic pathways and bioactive compounds such as anthocyanins. Conclusion: Research on red and purple berries and metabolic health has expanded considerably over the past decade, with increasing emphasis on mechanistic and interdisciplinary approaches. However, the predominance of review articles among the most highly cited publications highlights the need for more well-designed experimental and clinical research. Future studies should focus on strengthening the evidence base and advancing personalized nutrition strategies for the prevention and management of Type 2 diabetes.
Birinci basamakta çalışan sağlık profesyonellerinin kültürel yeterlilik düzeyleri ile zenofobi ilişkisi
(Marmara Sağlık Eğitim ve Araştırma Vakfı, 2026)
Erdem Şen, Kezban
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Yurt, Seher
Giriş: Küresel göç hareketlerinin artması, birinci basamak sağlık hizmetlerinde kültürel çeşitliliği belirgin biçimde artırmıştır. Farklı dil, inanç ve değerlere sahip bireylere eşitlikçi ve etkili bakım sunabilmek, sağlık profesyonellerinin kültürel yeterlilik düzeyleriyle yakından ilişkilidir. Buna karşın yabancılara yönelik olumsuz tutumlar (zenofobi), hizmet sunum sürecini olumsuz etkileyebilmektedir. Amaç: Bu çalışma, birinci basamakta çalışan sağlık profesyonellerinin kültürel yeterlilik ve zenofobi düzeylerini belirlemek, sosyodemografik değişkenlere göre farklılaşma durumlarını incelemek ve iki değişken arasındaki ilişkiyi ortaya koymak amacıyla yapılmıştır. Yöntem: Tanımlayıcı ve ilişki arayıcı kesitsel tipteki araştırma, Aralık 2024–Ekim 2025 tarihleri arasında İstanbul İl Sağlık Müdürlüğü’ne bağlı aile sağlığı merkezlerinde yürütülmüştür. Evreni 1793 sağlık profesyoneli oluşturmuş, örneklem formülü ile 317 katılımcıya ulaşılmıştır. Veriler Tanımlayıcı Bilgi Formu, Birinci Basamakta Çalışan Sağlık Personelinin Kültürel Yeterlilik Ölçeği ve Zenofobi Ölçeği ile toplanmış; analizler SPSS 22.0 programında gerçekleştirilmiştir. Bulgular: Katılımcıların kültürel yeterlilik puan ortalaması 71.70±12.84 (orta–yüksek düzey), zenofobi puanı 39.72±11.54 (düşük–orta düzey) olarak bulunmuştur. Kültürel yeterlilik ile zenofobi arasında anlamlı ve negatif yönlü ilişki saptanmıştır (r=–0.385; p<0.01). Regresyon analizinde kültürel yeterlilik, zenofobinin anlamlı bir yordayıcısı olup varyansın %14.5’ini açıklamaktadır (R²=0.145; p<0.001). Yüksek gelir, lisansüstü eğitim, yabancı dil bilme ve yurtdışı deneyimi kültürel yeterliliği artırırken; düşük yaş, düşük gelir ve eğitim düzeyi zenofobi ile ilişkili bulunmuştur. Sonuç: Kültürel yeterlilik arttıkça zenofobik eğilimlerin azaldığı belirlenmiştir. Birinci basamakta kültürel yeterlilik temelli eğitimlerin yaygınlaştırılması, hizmet kalitesinin ve toplum sağlığının geliştirilmesine katkı sağlayabilir.