DSpace Arşivi :: Ana Sayfa

İstanbul Kent Üniversitesi Araştırma ve Akademik Performans Sistemi

DSpace@Kent, İstanbul Kent Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.

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Tooth discoloration induced by calcium silicate-based cements: Effect of dentin surface pre-treatments in regenerative endodontics
(Springer Nature, 2026) Şeşen Uslu, Yeşim; Şeşen, Pınar; Özyürek, Taha; Arıcan, Burçin
This in vitro study evaluated whether dentin bonding agent application or Nd: YAG laser irradiation can reduce tooth discoloration induced by different calcium silicate–based cements (CSCs) under blood-contaminated conditions simulating regenerative endodontic procedures. Ninety extracted human maxillary incisors were standardized and randomly assigned to nine groups (n = 10) according to pre-treatment strategy (no treatment, universal adhesive, or Nd: YAG laser) and CSC type (ProRoot MTA, Biodentine, or TheraCal PT). Following blood application and clot formation, Spongostan and the assigned CSC were placed in the coronal third of the canal. Specimens were restored with resin composite and stored at 37 °C and 100% humidity. Color measurements were performed spectrophotometrically at baseline and after 7, 30, 90, and 180 days. Color changes were calculated using ΔE₀₀ and whiteness index difference (ΔWID) values. Data were ana lyzed using three-way repeated-measures ANOVA and Sidak post hoc tests (α = 0.05). All groups exhibited time-dependent discoloration. In ProRoot MTA groups, both dentin bonding agent and Nd: YAG laser pre-treatments significantly reduced discoloration compared with untreated controls (p < 0.05), with no significant difference between the two approaches (p > 0.05). Biodentine and TheraCal PT demonstrated significantly greater color stability than ProRoot MTA (p < 0.05). Within the limitations of this study, neither dentin bonding agent nor Nd: YAG laser pre-treatment completely prevented CSC-related discoloration. ProRoot MTA showed the greatest discoloration potential, even after preventive dentin pre treatment, and therefore may not be the preferred material for anterior regenerative endodontic cases in which esthetics are critical. Biodentine and TheraCal PT demonstrated better color stability and may be more suitable alternatives for esthetically demanding regions, while dentin bonding or Nd: YAG laser pre-treatment appears to provide only limited, material-dependent benefit.
Personalized, physiotherapist-guided exercise programs in juvenile ıdiopathic arthritis: Home-based vs. ımmersive virtual reality (JiaFitXR)
(Oxford University Press, 2026) Arman, Nilay; Albayrak, Asya; Dönmez, İrem; Açıkgöz, Yusuf; Yekdaneh, Asena; Çakmak, Figen; Sözeri, Betül; Aktay Ayaz, Nuray
Objective: To compare the effects of two physiotherapist-guided, personalized, stepwise-adapted exercise interventions—a home-based program (HomeEX) and an immersive virtual reality (IVR) exergaming program (JiaFitXR)—on physical fitness, functional capacity, and physical activity in adolescents with juvenile idiopathic arthritis (JIA). Methods: This randomized controlled trial included 50 adolescents aged 13–18 years with JIA, randomly assigned (1:1) to HomeEX or JiaFitXR. Both programs targeted balance, strength, endurance, and agility, delivered twice weekly for eight weeks under physiotherapist supervision. Functional capacity (6-Minute Walk Test, Sit-to-Stand, Step-Up/Step-Down tests) and physical fitness (FitnessGram components, muscle strength, EMG activation, grip force) were assessed pre- and post-intervention by blinded physiotherapists. Analyses were performed using paired and independent t-tests and repeated-measures ANOVA, following the intention-to-treat principle. Results: Both physiotherapist-guided interventions significantly improved physical fitness, functional capacity, and daily activity (p<0.05). Greater gains in 1-Minute Sit-to-Stand, Step-Up, and Step-Down tests, as well as in lower extremity endurance and neuromuscular activation, were observed in the JiaFitXR group (p<0.05). The HomeEX group showed superior improvements in flexibility and upper extremity strength (p<0.05). Step counts increased similarly in both groups, while perceived exertion remained stable throughout the program. Conclusion: Both physiotherapist-guided exercise approaches effectively enhanced physical and functional outcomes in adolescents with JIA. The IVR-based intervention provided additional benefits in lower extremity endurance and engagement, supporting its potential as an innovative and motivating adjunct to pediatric rheumatology rehabilitation.
Effects of integrated inspiratory–expiratory muscle training within hybrid cardiac rehabilitation following cardiac surgery: A randomized controlled study
(Elsevier, 2026) Ülker Ekşi, Büşra; Emirza Cilbir, Çiğdem; Uçgun, Hikmet; Ertan Harputlu, Özge; Kuran Aslan, Gökşen; Ezelsoy, Mehmet; Uğurlucan, Murat; Ertan Sağbaş, Liva; Akıncı, Buket
Background: Cardiac surgery may reduce pulmonary function, respiratory muscle strength, and functional capacity after surgery. Respiratory muscle training (RMT) is recommended in cardiac rehabilitation; however, evidence regarding RMT within HCR remains limited. Objective: To evaluate the effects of adding RMT to an HCR program following cardiac surgery in a randomized controlled trial. Methods: In this randomized controlled trial, 20 patients were randomized to HCR (n=10) or HCR+RMT (n=10). Rehabilitation started in postoperative week 1 and continued for 8 weeks. Both groups received HCR, while the HCR+RMT group performed combined inspiratory and expiratory muscle training. Primary outcomes were pulmonary function, respiratory muscle strength, and 6-minute walk distance. Secondary outcomes included quality of life, physical activity, usability, feasibility, and satisfaction. Results: Twenty participants completed the study, with 100% retention and attendance in both groups and no adverse events. At postoperative week 1, respiratory and functional parameters declined in both groups. By week 8, 6-minute walk distance increased by 49.5 m in the HCR group and 55.5 m in the HCR+RMT group. Duke Activity Status Index scores improved by 5.25 and 4.95 points, respectively, while Minnesota Living with Heart Failure Questionnaire scores decreased by 7–9 points. No significant between-group differences were found for any outcome (all p>0.05). Conclusions: Adding RMT to HCR is feasible, safe, and well accepted. Both interventions improved respiratory function, respiratory muscle strength, functional capacity, physical activity, and quality of life. Although no additional short-term benefit was observed with RMT, it may be considered complementary to HCR programs.
Impact of COVID-19 vaccine type on the efficacy and safety of Nivolumab in patients with metastatic non-small-cell lung cancer: A multicenter study
(HighWire, 2026) Karabuğa, Berkan; Büyükkör, Mustafa; Karaçin, Cengiz; Karabuğa, Ekin Konca; Yıldız, Sedat; Güneysu, Gökçe Gül; Akgüner, Güner; Keskin Uzundere, Fatma; Arslan, Ayşe; Davarcı, Sena Ece; Urakçı, Zuhat; Sütçüoğlu, Osman; Yıldırım, Özgen Ahmet; Karadurmuş, Nuri; Ergün, Yakup
Background/Aim: The effect of COVID-19 vaccine type on the outcomes of therapy immune checkpoint inhibitors remains unclear, and concerns persist regarding whether mRNA-based vaccines may negatively impact treatment efficacy or increase immune-related toxicity. This study aimed to evaluate the association between COVID-19 vaccination type and the efficacy and safety of nivolumab in patients with metastatic non-small-cell lung cancer (NSCLC). Patients and Methods: We retrospectively analyzed 138 patients with driver-negative metastatic NSCLC treated with second-line nivolumab. Patients were classified as receiving virion-based (Sinovac) only, mRNA-based only, or both types of vaccines. Treatment response, progression-free survival, objective response rate, clinical benefit rate clinical benefit rate and immune-related adverse events were compared. Results: The overall response and clinical benefit rates were similar across vaccination groups, with no significant differences observed (p=0.38 and p=0.16, respectively). Median progression-free survival did not differ significantly among the different groups (p=0.39). The incidence of any-grade and grade 3-4 immune-related adverse events was comparable across groups, although grade 1-2 immune-related adverse events were more frequent among patients who had received at least one dose of Sinovac. Conclusion: In patients with metastatic NSCLC receiving second-line nivolumab, the efficacy and safety profile of nivolumab did not differ according to the type of COVID-19 vaccine patients had received prior to therapy.
Yönetimde karar verme süreci
(Nobel Akademik Yayıncılık, 2025) Bektaş, Gülfer; Özcan Ünal, Birsen
Günümüz modern iş dünyasında, her alanda önemli değişim ve gelişmeler yaşanmakta ve bu değişimlerden toplumun büyük bir kısmı etkilenmektedir. Bu durumda hem bireyler hem de kurumlar için sağlıklı ve başarılı kararlar almak hayati önem taşımaktadır. Bu nedenle ayakta kalabilmek ve sürdürülebilir bir rekabet avantajı sağlamak, etkili karar verme becerisini gerektirmektedir.