İstanbul Kent Üniversitesi Araştırma ve Akademik Performans Sistemi
DSpace@Kent, İstanbul Kent Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
Güncel Gönderiler
Öğe Türü:Öğe, Radiation exposure in thyroid cancer patients treated with radioiodine: A dental perspective(Galenos Publishing House, 2026) Akdoğan, Emine Tuna; Demir, MustafaIntroduction: This study aimed to experimentally determine radiation safety criteria for dentists who examine or treat patients receiving radioactive iodine (RAI) therapy for the follow-up of differentiated thyroid cancer in the nuclear medicine department. Methods: Twenty-three patients undergoing whole-body scintigraphy with RAI were included. Each patient received 185 MBq of RAI orally on an outpatient basis and remained in lead-shielded isolation rooms for approximately two hours to allow for systemic distribution. Dose-rate measurements were then obtained along a horizontal line at distances of 5, 15, 30, 60, and 100 cm from the neck and abdominal regions. Results: During the first 0–2 hours, mean dose rates measured from the neck at 5, 15, 30, 60, and 100 cm were 584±120 µSv/h, 312±52 µSv/h, 175±36 µSv/h, 18±6 µSv/h, and 11±4 µSv/h, respectively. Based on these data, the estimated radiation dose to a dentist during close contact (5–30 cm) was 224 µSv on the first day, 117 µSv on the second day, and 3 µSv on the third day after administration. Conclusion: The permissible chairside exposure time on the first day was estimated at approximately 3.12 hours without exceeding safety limits. However, when daily dose limits derived from annual occupational exposure are considered, the third day after RAI administration was identified as the safer period for dental procedures.Öğe Türü:Öğe, Global pilot prospective multicentre study to classify flexible ureteroscopy with FANS and report peri and 30 day post operative ouctomes in a multicentre real world setup by EAU Endourlogy(Elsevier, 2026) Gauhar, V.; Castellani, D.; Fong, K.Y.; Angerri, O.; Soebhali, B.; Du, J.; Tanıdır, Yılören; Tzelves, L.; Petkova, K.; Rico, L.; Sen, V.; Tefik, T.; Demirkiran, E. D.; Idrissa, S.; Vidal, E. Politi; Sytnik, D.; Parikesit, D.; Tsaturyan, A.; Mazzon, G.; Elshazly, M.; Geavlete, P.; Ferreti, S.; Somani, B. K.; Yuen, S. K. K...Öğe Türü:Öğe, Avrupa Birliğinde uygulanan koruma yaklaşımları ve Türkiye’de korunan alanların yasal statü ve kategorilerle incelenmesi(Artvin Çoruh Üniversitesi, 2026) Altınkaya, Fadime; Kardaş, Gamze; Say, Nuriye; Kamińska, Martyna; Yaptaterek, BengiYaşanabilir bir çevre oluşturmak ve biyolojik çeşitliliği korumak yalnızca ulusal değil, küresel bir sorumluluktur. Bu doğrultuda dünya ülkeleri, doğal kaynakları korumaya yönelik statüler ve hedefler geliştirmiştir. Türkiye’de statüler uluslararası koruma sistemleri ile benzerlik gösterse de korunan alanların tespit, tescil, onay ve yönetim süreçlerinde sorunlar yaşanmaktadır. Aynı alanın farklı mevzuatlara göre birden fazla statüde tanımlanması ve bu statülerin farklı kurumlarca yönetilmesi, uygulamada zorluklara yol açmaktadır. Bu çalışmada, öncelikle kuramsal bir çerçeve oluşturulmuş; ardından analiz-sentez süreciyle Avrupa Birliği çevre politikalarıyla uyumlu olarak uygulanan uluslararası koruma sistemleri ile Türkiye’deki koruma yaklaşımları karşılaştırılmıştır. Üç örnek korunan alan türü olan IUCN Kategori I.b kapsamında değerlendirilen Milli Park, Yaban Hayatı Geliştirme Sahaları, Ramsar Sözleşmesi kapsamında Ramsar Alanları üzerinden yasal, yönetsel ve uygulamaya dair çelişkiler tartışılmış; alanın yeri ile ilgili, alanın yapısı ile ilgili ve alanın gelişimi ile ilgili kriterler çerçevesinde değerlendirilmiştir. Alanın yeri ile ilgili kriterler; büyüklük, yer (konum), ulaşım başlıklarında değerlendirilmiştir. Alanın yapısı ile ilgili kriterler; korunan alanlarda incelenecek ekolojik kriterler çerçevesinde detaylandırılmış (doğallık, tehlike altında olma, yenilenemezlik, zenginlik, azlık enderlik, bütünlük, temsil yeteneği) başlıklarında, alanın gelişimi ile ilgili kriterler ise korunan alana gelen ziyaretçilerin alanın özellik ve karakteristiğini bozmadan barındıracak tesislerin yapılması, gerekli yerlerde koruma-kullanım dengesi gözetilerek yapılan planlama çalışmaları, alanın bakımı ve temizliği ile idari ve teknik personel çerçevesinde değerlendirilmiştir. Tabiatı ve Biyolojik Çeşitliliği Koruma Yasa Tasarısı’na da yer verilerek mevcut sorunların giderilmesine yönelik sonuç ve öneriler geliştirilmiştir.Öğe Türü:Öğe, Quantitative EEG assessment of dependence-related neurophysiological patterns using rule- and score-based modeling in substance use disorders(MDPI, 2026) Gürbüz, Merve Setenay; Gül, Özlem; Ekşi, Eslem Fulya; Ögel, KülteginBackground and Objectives: Substance use disorders (SUDs) are associated with maladaptive neuroplasticity and chronic dysregulation of cortical arousal. EEG provides a non-invasive tool for quantifying these neurophysiological alterations through spectral power and reactivity indices. Prior research consistently reports elevated beta and diminished alpha activity in SUD, reflecting cortical hyperarousal and reduced inhibitory control. This study sought to identify EEG-based markers of dependence-related neurophysiological alterations by integrating rule-based and score-based models incorporating the theta/beta ratio (TBR), alpha and beta powers, the hyperarousal index, and alpha-blocking measures. Materials and Methods: EEG recordings from 47 individuals with SUD were systematically analyzed, focusing on frontal and central cortical regions. Spectral parameters were derived using power spectral density estimation, and composite indices were computed via Python based signal analysis. A rule-based Dependence Likelihood variable and a continuous Dependence Score (0–1 scale) classified cases as dependence-related (≥0.7), borderline (0.5–0.7), or normal (<0.5). Results: Low alpha power and an elevated hyperarousal index (mean = 3.45) characterized most participants. Dependence-related EEG profiles were identified in 87.2% of cases (mean score = 0.86). Alpha blocking remained intact in 46.8% of cases, whereas post-hyperventilation recovery was attenuated in 61.7% of cases. Segmental analysis indicated sustained cortical activation with low TBR (0.37) and elevated beta across all conditions. Conclusions: Quantitative EEG analysis revealed consistent hyperarousal and inhibitory deficits in SUD. The combined Dependence Likelihood and Score framework provides an interpretable, reproducible approach for identifying dependence-related EEG signatures and holds promise as a biomarker in addiction neurophysiology.Öğe Türü:Öğe, Insights on medical therapy for uterine fibroids: A review(Springer Nature, 2026) Pecorella, Giovanni; Morciano, Andrea; Sparic, Radmila; Hatırnaz, Şafak; Medvediev, Mykhailo; Malvasi, Antonio; Damiani, Gianluca Raffaello; Tinelli, AndreaUterine fibroids constitute the most preva lent benign neoplasms within the female reproductive system, impacting a substantial proportion of women by the age of 50 years. While a significant number of these tumors remain asymptomatic, they have the potential to induce abnormal uterine bleeding (AUB), pelvic discomfort, pain, anemia, and infer tility, thereby considerably diminishing the quality of life. Pharmacological intervention occupies a pivotal position in the manage ment of fibroids, particularly for individu als who desire to preserve uterine function, postpone surgical intervention, or opt for noninvasive alternatives. Over the preceding two decades, the landscape of medical treat ment has undergone significant expansion. Conventional therapeutic options, such as GnRH agonists and hormonal contraceptives, continue to be beneficial in specific contexts; however, their limitations regarding toler ability, skeletal safety, and sustained efficacy are widely acknowledged. Oral GnRH antago nists, which include elagolix, relugolix, and linzagolix, signify a substantial progression, providing rapid and reversible suppression of ovarian hormone synthesis with dose dependent effects and enhanced convenience. Clinical investigations demonstrated substan tial reductions in excessive menstrual bleed ing, enhancements in anemia, and improve ments in quality of life associated with these pharmacological agents, particularly when administered in conjunction with hormonal add-back therapy. Alternative interventions, including selective progesterone receptor modulators (SPRMs), progestins, aromatase inhibitors, and antifibrinolytics, exhibit vari able effectiveness and are optimally utilized within defined clinical frameworks. Con cerns regarding safety, especially in relation to hepatic toxicity associated with SPRMs, have prompted regulatory limitations and underscore the necessity for ongoing pharma covigilance. Tailored therapeutic approaches that consider reproductive objectives, symp tomatology, comorbid conditions, and patient preferences are of paramount importance. Innovative treatment modalities that target nonhormonal mechanisms, such as extracel lular matrix remodeling, angiogenesis, and gene modulation, provide promising pros pects for future uterus-sparing interventions. This narrative review evaluates the current and advancing landscape of medical thera pies for uterine fibroids, presenting evidence based perspectives to inform clinical decision making within an increasingly personalized therapeutic context.
