İstanbul Kent Üniversitesi Araştırma ve Akademik Performans Sistemi
DSpace@Kent, İstanbul Kent Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
Güncel Gönderiler
Öğe Türü:Öğe, Association between childhood adversities and mental well-being in young adults: The mediational role of negative metacognitive beliefs(Springer Nature, 2025) Akça, Erdoğdu; Demirok, Zeynep Nur; Usta, Elvan Başak; Gürcan, Mehmet Buğrahan; Gündüz, AnılAdverse childhood experiences (ACEs) have long been known to convey cumula tive risks for poor mental outcomes in later years. The evidence on association between ACEs, mental well-being (MWB) and their interaction process in young adults is scarce. We sought to adapt the mediational role of metacognitive beliefs within the psychopathological framework to perceived mental health conception. Participants were college students (N=144, mean age 21.13 (SD=3.30), 119 fe males) who completed online questionnaire battery evaluating sociodemographic features, ACEs, pathologic worrying, state anxiety, metacognitive beliefs, and men tal well-being. Significant associations were found among ACEs, MWB, worry, anxiety, and metacognitive beliefs. When MWB was regressed on all predictors (ACEs, worry, anxiety, and metacognitive beliefs), uncontrollability and danger (UD) remained the only significant metacognitive belief alongside these variables. In the subsequent analyses, the role of UD was evident in the more parsimonious models; however, the additional indirect associations was not significant once both worry and state anxiety were incorporated in the structural equation. Our results suggest that metacognitions may represent an important correlate of the associa tions between ACEs and MWB in early adulthood. Negative beliefs might be a interventional target to promote MWB before developing anxiety symptoms for college students at risk for ACEs.Öğe Türü:Öğe, Serum trimethylamine-n-oxide and its precursors as a diagnostic biomarker panel for non-muscle-invasive bladder cancer(MDPI, 2026) Baltacıoğlu, Aleyna; Acar, Osman; Sönmez, Ceyda; Sağlıcan, Yeşim; Argun, Ömer Burak; Kural, Ali Rıza; Yıldırım, Asıf; İnce, Ümit; Serdar, Muhittin Abdülkadir; Özpınar, AyselNon-muscle-invasive bladder cancer (NMIBC) is characterized by high recurrence rates and necessitates lifelong cystoscopic surveillance, underscoring the need for minimally invasive biomarkers to improve early detection and risk stratification. Therefore, this study aimed to investigate the role of trimethylamine-N-oxide (TMAO) and its precursors as diagnostic biomarkers for NMIBC. A total of 50 male patients with NMIBC (25 pTa and 25 pT1) were included in this study. Additionally, 52 age-matched healthy individuals were included as controls. Serum TMAO and its dietary precursors were quantified using liquid chromatography–tandem mass spectrometry. Group differences were analyzed using nonparametric tests, associations were assessed using Spearman’s correlation, and diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis. Multivariate logistic regression was performed to identify independent predictors, and a composite risk score was generated. Serum TMAO, carnitine, and choline levels were significantly higher in patients with NMIBC than in controls (p ≤ 0.0001), whereas betaine showed a nonsignificant trend toward higher levels (p ≥ 0.05). The pathological stage (pTa vs. pT1) showed the strongest correlation with TMAO levels. The ROC analysis revealed that TMAO had the highest individual diagnostic accuracy (area under the curve [AUC] = 0.875, 95% confidence interval [CI] 0.812–0.939), whereas carnitine and choline provided complementary diagnostic performance. In multivariate models, TMAO, carnitine, and choline remained independent predictors of NMIBC (p ≤ 0.0001). A composite risk score integrating all four metabolites demonstrated excellent discriminatory capacity (AUC = 0.958, 95% CI 0.926–0.991). The TMAO metabolic axis can be used as a minimally invasive biomarker panel for NMIBC. Further large, prospective, multicenter studies integrating metabolomic and microbiome profiling are needed to validate the findings.Öğe Türü:Öğe, Artificial Intelligence for business model innovation in digital sustainability companies: Multiple cases from the Netherlands(World Association for Sustainable Development, 2026) Mohamad, Mostafa; Balıkel, Ali Eren; Chowdhury, Dababrata; Russell, Christopher; Eldebeky, Sayed M.PURPOSE: We explore how sustainability companies deliver Artificial Intelligence powered (AI-Powered) solutions for Business Model Innovation (BMI) and how they balance between ecological, economic, and social value across diverse industries and company sizes. DESIGN/METHODOLOGY/APPROACH: We adopt qualitative semi-structured interviews with the top 20 sustainability executives and founders in the Netherlands as a unique context of sustainability. FINDINGS: We found differences between large and small sustainability companies from the Technological, Organisational, and Environmental (TOE) perspectives. Technically AI is instrumental for operational efficiency, real-time environmental monitoring, and supply chain traceability. Organisationally, sustainability companies focus on design-led approaches, bottom-up innovation, and AI–strategy alignment. Environmentally, they face challenges such as supply chain collaboration resistance, the impact of regulation, and market readiness. ORIGINALITY/VALUE OF THE PAPER: This study offers original multi-case evidence from the Netherlands, providing a systemic framework based on the TOE theory to reconceptualise AI not just as a facilitator but as a foundational input shaping sustainable BMI. PRACTICAL IMPLICATIONS: It guides sustainability executives and SMEs’ founders to embed AI efficiently to align with client values.Öğe Türü:Öğe, Letter to the Editor: Neonatal airway ultrasound, useful reference, limited guidance for anesthesiologists(Springer Nature, 2026) Kuratani, Norifumi; Ustalar Özgen, Zehra Serpil; Ponde, Vrushali; Holzki, JosefWe read with great interest the prospective study by Paprocki and colleagues establishing ultrasound (US) reference values for laryngeal and tracheal structures in 300 healthy neonates examined in the first days of life. The authors should be commended for generating sex stratified percentile data under standardized conditions and for demonstrating bedside feasibility—contributions that advance image-based assessment in neonatology and pediatrics.Öğe Türü:Öğe, EU Ecolabel diffusion and circular material use: Evidence from EU countries and implications for sustainable business models(MDPI, 2026) Atabay, Esra; Sis Atabay, Elif; Gökmen, Ahmet MünirThe transition from a linear to a circular economy has intensified interest in environmentally friendly business models and policy instruments that support sustainable production and consumption. While prior research has largely examined green labels at the micro level, focusing on consumer perceptions and purchase intentions, limited evidence exists on their macro-level role in circular economic performance. This study tests the hypothesis that higher EU Ecolabel diffusion is positively associated with circular material use rates (CMUR) across European Union Member States over the period 2010–2024. This study does not directly measure business models but examines macro-level indicators associated with their development. Using panel data from Eurostat and the European Commission’s EU Ecolabel catalogue, ecolabel intensity is operationalized as the logarithm of total licenses per country. Pooled OLS models with year fixed effects and country-clustered standard errors are estimated, first in baseline specification and then with controls for GDP per capita, environmental tax revenues, manufacturing value added, and R&D intensity. Results reveal a positive and statistically significant relationship between ecolabel intensity and circular material use rates, remaining robust after including macroeconomic controls. These findings suggest that green labeling is associated with circular economy performance and may reflect an institutional dimension aligned with circular economy governance. The results are also consistent with patterns associated with environmentally friendly business models at the macro level. This study contributes by providing a macro-level, cross-country analysis of the relationship between EU Ecolabel diffusion and circular economy performance, incorporating key structural controls.
