Browsing by Author "Çam, Muhammet Emin"
Now showing items 1-20 of 23
-
Anti-Alzheimer's effect of memantine/donepezil/metformin-loaded PVA/PEO composite nanofibers produced by pressurized gyration: Production, characterization, and in vitro evaluation
Güler, Ece; Kopuz, Ayşen; Ertaş, Büşra; Yılmaz Göler, Ayşe Mine; Yazır, Yusufhan; Kalaskar, Deepak M.; Çam, Muhammet Emin (Editions de Sante, 2024)In this study, memantine (MM) and donepezil (DO) were combined with metformin (MF) as a new approach to Alzheimer’s disease (AD) treatment sublingually. MM, DO, and MF were loaded in polyvinyl alcohol (PVA)/ polyethylene ... -
Antimicrobial effects of silver nanoparticles possibly used in food packaging
Ercan, Gülsüm; Parviz, Gita; Rayaman, Erkan; Çam, Muhammet Emin (Kızılay Culture and Art, 2025)Microbial contamination in food industry is a major issue resulting in wast ed products and poses a threat to public health through foodborne illnesses. Silver nanoparticles (AgNPs) have strong antimicrobial properties ... -
Antiviral properties of essential oil mixture: Modulation of E7 and E2 protein pathways in human papillomavirus (HPV) infection
Üner, Burcu; Güler, Ece; Vicir, Mustafa Emrah; Kayhan, Hülya; Atsü, Necmettin; Kalaskar, Deepak; Çam, Muhammet Emin (Elsevier, 2024)Ethnopharmacological relevance: Clove is used in Indian and Chinese traditional medicine for viral diseases. Palmarosa essential oils have been traditionally used in India and Southeast Asia since ancient times and ... -
Characterization and anti-Alzheimer's effect of donepezil-loaded chitosan/polyethylene glycol nanospheres
Parviz, Gita; Güler, Ece; Hazar Yavuz, Ayşe Nur; Yekeler, Hümeyra Betül; Tatar, Esra; Koçar, Feyza; Sermet, Sinan; Asghar, Asima; Wang, Xiaofeng; Ikram, Fakhera; Kalaskar, Deepak M.; Çam, Muhammet Emin (Editions de Sante, 2025)Among numerous dysfunctions associated with Alzheimer’s disease, cholinergic deficiency has been postulated as evidently influential. Despite donepezil’s ability to decelerate disease progression, drug’s pharmacokinetic ... -
A comparison of electrospinning and pressurized gyration: Production of empagliflozin-loaded polylactic acid/ polycaprolactone fibrous patches
Yekeler, Hümeyra Betül; Kabaoğlu, İlke; Güler, Ece; Graça, Manuel Pedro F.; Gündüz, Oğuzhan; Kalaskar, Deepak M.; Çam, Muhammet Emin (Royal Soc, 2025)Novel therapeutic strategies are essential for enhancing efficacy and accelerating the treatment of diabetes mellitus. This investigation focused on incorporating empagliflozin into a composite of polylactic acid ... -
Comparison of the effect of UVB application on the antioxidant properties of different mushroom species with vitamins D2 and D3
Cebeci, Aybike; Taşkın, Turgut; Aktaç, Şule; Çam, Muhammet Emin; Sancı, Rıfat Sami; Güneş, Fatma Esra (Marmara University, 2024)This study aimed to determine the effect of UVB application on different mushrooms and their antioxidant properties and compare their properties with pure vitamins D2 and D3. In the study, as without UVB, with medium UVB ... -
Design and in vitro evaluation of curcumin-loaded PLGA nanoparticle-embedded sodium alginate/gelatin 3D printed scaffolds for Alzheimer’s disease
Yekeler, Hümeyra Betül; Güler, Ece; Beato, Patricia Santos; Priya, Sushma; Abobakr, Fatima Khaled Mohammed; Doğan, Murat; Üner, Burcu; Kalaskar, Deepak M.; Çam, Muhammet Emin (Elsevier, 2024)Background: Targeted nanoparticles (NPs) are aimed at improving clinical outcomes by enhancing the diagnostic and therapeutic efficacy of drugs in the treatment of Alzheimer’s disease (AD). Methods: Curcumin (CUR)-loaded ... -
Development and characterization of liposomal systems for improved resveratrol delivery
Abobakr, Fatima Khaled Mohammed; Çam, Muhammet Emin (Kızılay Culture and Art, 2025)After the COVID-19 pandemic, consumer awareness of health and wellness has increased global interest in dietary supplements. The global food sup plement market has grown rapidly and is expected to continue. Resveratrol ... -
Donepezil/Curcumin-Loaded Nanoparticles-Embedded Microneedles for the treatment of Alzheimer’s disease: In vitro evaluation
Parviz, Gita; Çam, Muhammet Emin (Avestia Publishing, 2024)Alzheimer’s disease (AD) is an insidious neurodegenerative disease that slowly deteriorates and seriously impairs the activity of daily living (ADL) of those who suffer from. Although the precise pathophysiology of AD ... -
Evaluation of the mesalazine-loaded nanoparticles-embedded BSA hydrogels for the ulcerative colitis treatment
Güler, Ece; Abobakr, Fatima Khaled Mohammed; Taşpınar, Yağmur Mehtap; Bostan, Müge Sennaroğlu; Eroğlu, Mehmet Sayip; Çam, Muhammet Emin (ACG Publications, 2024)Ulcerative colitis (UC) is a chronic inflammatory bowel disease mainly affecting the colon and remains a challenging disease to manage clinically with its relapsing-remitting course. Traditional treatments for this ... -
Fabrication of oro-dispersible sodium valproate loaded nanofibrous patches for immediate epileptic innervation
Güler, Ece; Yekeler, Hümeyra Betül; Özdemir Kumral, Zarife N.; Parviz, Gita; Özcan, Gül S.; Üner, Burcu; Demirbaş, Sinem G.; Ayyıldız, Simge; Yazır, Yusufhan; Kalaskar, Deepak; Çam, Muhammet Emin (American Chemical Society, 2024)Epilepsy is one of the oldest neurological disorders discovered by mankind. This condition is firmly coupled with unprovoked seizures stimulated by irrepressible neuroelectrical blasts. Orally taken valproate family has ... -
Gilaburu (Viburnum opulus L.) fruit extract has potential therapeutic and prophylactic role in a rat model of acetic acid-induced oxidant colonic damage
Gülada, Begümhan Ömeroğlu; Çam, Muhammet Emin; Yüksel, Meral; Akakın, Dilek; Taşkın, Turgut; Emre, Gizem; Şener, Göksel; Karakoyun, Berna (Elsevier, 2024)Ethnopharmacological relevance: Ulcerative colitis (UC) which has a global impact on the health care system with its recurrent and incompletely curable characteristics, affects the patients’ quality of life. Gilaburu (GB; ... -
In vitro investigation of antimicrobial activities of Camellia sinensis, Salvia officinalis, Aloe vera and Thymus vulgaris
Tekinalp, Şevval Gülşah; Rayaman, Erkan; Çam, Muhammet Emin (Kızılay Culture and Art, 2025)Acne vulgaris is a skin condition that affects people of various age groups worldwide. It can lead to psychological disorders by negatively impacting individuals’ social lives, self-confidence, physical appearance, and ... -
In vitro neuroprotective effect evaluation of donepezil-loaded PLGA nanoparticles-embedded PVA/PEG nanofibers on SH-SY5Y cells and AP-APP plasmid related Alzheimer cell line model
Güler, Ece; Yekeler, Hümeyra Betül; Üner, Burcu; Doğan, Murat; Asghar, Asima; Ikram, Fakhera; Yazır, Yusufhan; Gündüz, Oğuzhan; Kalaskar, Deepak M.; Çam, Muhammet Emin (John Wiley and Sons Inc, 2024)Recently developed nanoparticles and nanofibers present new brain-specific treatment strategies, especially for Alzheimer's disease treatment. In this study, donepezil (DO)-loaded PLGA nanoparticles (DNP) are embedded in ... -
Investigation of the antimicrobial activity of some plant extracts
Yekeler, Hümeyra Betül; Rayaman, Erkan; Çam, Muhammet Emin (Kızılay Culture and Art, 2025)The use of antimicrobial plants in mineral water prevents the growth of pathogenic microorganisms, extends the shelf life of the product, and pro vides a natural alternative to chemical preservatives (1). Furthermore, ... -
The methanolic extracts of Teucrium polium L. and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis improve diabetes in streptozotocin/nicotinamide-induced type 2 diabetic female Sprague Dawley rats
Sermet, Sinan; Çam, Muhammet Emin; Hazar Yavuz, Ayşe Nur; Taşkın, Turgut; Kabataş, Gül Sinemcan; Yazır, Yusufhan; Kabasakal, Levent; Elçioğlu, Hatice Kübra (Elsevier, 2023)Background: Teucrium polium and Micromeria fruticosa subspecies are known to be used in tradi tional medicine for diabetes treatment. Objective: The present study aimed to examine the potential antidiabetic effects and ... -
A novel high-efficiency transdermal patches for combinational therapy of Alzheimer's disease: Donepezil/vitamin B12-loaded nanofibers
Ertaş, Büşra; Onay, İrem Nur; Yılmaz Göler, Ayşe Mine; Karademir Yılmaz, Betül; Aslan, İsmail; Çam, Muhammet Emin (Editions de Sante, 2023)Improving clinical practice in disease-modifying therapies is an important strategy in coping with the progressive course of Alzheimer’s Disease (AD). This study aimed to develop DO and VB12-loaded nanofibers (DO/VB12- ... -
Novel hydrazide-hydrazone containing 1,2,4-triazole as potent inhibitors of antiapoptotic protein Bcl-xL: Synthesis, biological evaluation, and docking studies
Kuran, Ebru Didem; Üner, Burcu; Çam, Muhammet Emin; Ulusoy Güzeldemirci, Nuray (John Wiley and Sons Inc, 2024)This study describes the synthesis and characterization of a series of novel hydrazide-hydrazone derivatives containing a 1,2,4-triazole ring. The compounds were characterized using various spectroscopic techniques, such ... -
The production of curcumin-loaded PLGA/PEG nanoparticle for the treatment of Alzheimer’s disease
Güler, Ece; Çam, Muhammet Emin (Marmara University, 2023)Alzheimer's disease (AD) is the most common type of dementia in the world. This neurodegenerative disease affects 6.5 million people's lives by leading to functional impairments such as memory loss and cognitive regression. ... -
The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus
Aydın, Saliha; Tekinalp, Şevval Gülşah; Tuzcu, Bilge; Furkan, Çam; Sevik, Mehmet Orkun; Tatar, Esra; Kalaskar, Deepak; Çam, Muhammet Emin (Elsevier, 2024)Type 2 Diabetes Mellitus (T2DM) is a growing health concern that leads to increased morbidity and mortality rates worldwide. A protein complex called AMP-activated protein kinase (AMPK) regulates energy balance within ...
